4-羰基-4-(2-吡啶基)丁酸合成路线 （共 7 条）
反应条件
sulfuric acid T=85°C;
参考文献
Atobe, Masakazu; Maekawara, Naomi; Ishiguro, Noriko; Sogame, Shinya; Suenaga, Yoshihito; Kawanishi, Masashi; Suzuki, Hiroko; Jinno, Norimasa; Tanaka, Eiichi; Miyoshi, Shiro
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 7 p. 2106 - 2110
反应条件
water; sodium hydroxide in methanol
T=20°C;
参考文献
Amat, Mercedes; Arroniz, Carlos; Molins, Elies; Escolano, Carmen; Bosch, Joan
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 7 p. 2175 - 2184
反应条件
1: NaH / tetrahydrofuran / 1.) 0 deg C, 10 min, 2.) 0 deg C, 5 h
2: TsOH / benzene / 16 h / Heating
3: aq. LiOH / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
Hoffman, Robert V.; Kim, Hwa-Ok
Journal of Organic Chemistry, 1995 , vol. 60, # 16 p. 5107 - 5113
反应条件
1: TsOH / benzene / 16 h / Heating
2: aq. LiOH / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
Hoffman, Robert V.; Kim, Hwa-Ok
Journal of Organic Chemistry, 1995 , vol. 60, # 16 p. 5107 - 5113
反应条件
1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere
2: water; sodium hydroxide / methanol / 20 °C
View Scheme
参考文献
Amat, Mercedes; Arroniz, Carlos; Molins, Elies; Escolano, Carmen; Bosch, Joan
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 7 p. 2175 - 2184
反应条件
1: oxalyl dichloride / 20 °C
2: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere
3: water; sodium hydroxide / methanol / 20 °C
View Scheme
参考文献
Amat, Mercedes; Arroniz, Carlos; Molins, Elies; Escolano, Carmen; Bosch, Joan
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 7 p. 2175 - 2184
反应条件
in 1,2-dichloro-ethane
29.5 h; Inert atmosphereReflux;
参考文献
Tsukano, Chihiro; Oimura, Atsuko; Enkhtaivan, Iderbat; Takemoto, Yoshiji
Organic Letters, 2012 , vol. 14, # 7 p. 1902 - 1905
