2-乙酰基-4,5-二氯噻吩合成路线 （共 8 条）
反应条件
1: 2,3-dichlorothiophene With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 0.5 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-78 - 20°C;
参考文献
AMGEN, INC.
Patent: WO2006/66172 A1, 2006 ;
Location in patent: Page/Page column 33-34 ;
WO 2006/066172 A1
反应条件
aluminium trichloride; chlorine in tetrachloromethane; chloroform T=30°C; 1.5 h;
参考文献
Stanetty, Peter; Puschautz, Erhard; Friedbacher, Gernot
Monatshefte fuer Chemie, 1989 , vol. 120, p. 53 - 63
反应条件
aluminium trichloride; Petroleum ether
参考文献
Justus Liebigs Annalen der Chemie, , vol. 532, p. 250,279
反应条件
zinc in water; acetic acid 2.5 h; Heating;
参考文献
Stanetty, Peter; Puschautz, Erhard; Friedbacher, Gernot
Monatshefte fuer Chemie, 1989 , vol. 120, p. 53 - 63
反应条件
1: 81 percent / Zn / H2O; acetic acid / 2.5 h / Heating 2: 1) NaOH, Cl2 / 1) H2O, -10 deg C, 2) 50 deg C View Scheme
参考文献
Stanetty, Peter; Puschautz, Erhard; Friedbacher, Gernot
Monatshefte fuer Chemie, 1989 , vol. 120, p. 53 - 63
反应条件
sodium hydroxide; chlorine 1) H2O, -10 deg C, 2) 50 deg C; Yield given. Multistep reaction;
参考文献
Stanetty, Peter; Puschautz, Erhard; Friedbacher, Gernot
Monatshefte fuer Chemie, 1989 , vol. 120, p. 53 - 63
反应条件
1: 81 percent / Zn / H2O; acetic acid / 2.5 h / Heating 2: 95 percent / Br2, AlCl3 / CHCl3 / 2 h / Heating View Scheme
参考文献
Stanetty, Peter; Puschautz, Erhard; Friedbacher, Gernot
Monatshefte fuer Chemie, 1989 , vol. 120, p. 53 - 63
反应条件
1: 81 percent / Zn / H2O; acetic acid / 2.5 h / Heating 2: 95 percent / Br2, AlCl3 / CHCl3 / 2 h / Heating 3: 1) NaOH, Cl2 / 1) H2O, -10 deg C, 2) 50 deg C View Scheme
参考文献
Stanetty, Peter; Puschautz, Erhard; Friedbacher, Gernot
Monatshefte fuer Chemie, 1989 , vol. 120, p. 53 - 63
