N-苄基-n-甲基-1H-苯并噻唑-1-甲胺合成路线 (共 2 条)
反应条件
1: bromo-difluoroacetic acid,ethyl ester With chloro-trimethyl-silane; zinc in tetrahydrofuran T=20°C; 0.166667 h; 2: isoprene in tetrahydrofuran T=20°C; 3 h;
参考文献
WO2013/4984 A1, ;
Page/Page column 68 ;
反应条件
in methanol; diethyl ether; water
Reflux;
参考文献
CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); MCNEENEY, Stephen, Phillip; PASTOR FERNÁNDEZ, Joaquín; MARTÍNEZ GONZÁLES, Sonia; MARTÍN HERNANDO, José Ignacio; RODRÍGUEZ HERGUETA, Antonio; RICO FERREIRA, María del Rosario; BLANCO APARICIO, Carmen
Patent: WO2013/4984 A1, 2013 ;
Location in patent: Page/Page column 67-68 ;