乙基6-甲基-3-氧代庚酸酯合成路线 （共 8 条）
反应条件
tin(ll) chloride in dichloromethane
T=25°C; 1.16667 h;
参考文献
Ellis, David; Li, Liansheng; Tran, Chinh V.; Ruebsam, Frank; Zhou, Yuefen
Patent: US2009/62263 A1, 2009 ;
Location in patent: Page/Page column 29 ;
US 20090062263 A1
反应条件
1: 4-methylpentanoic acid With carbonyldiimizadole in tetrahydrofuran
T=20°C; 20 h;
2: Mg(O2CCH2CO2Et)2 in tetrahydrofuran
T=20°C; 24 h;
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.; MITCHELL, Ian S.; BLAKE, James F.; XU, Rui; KALLAN, Nicholas C.; XIAO, Dengming; SPENCER, Keith Lee; BENCSIK, Josef R.; LIANG, Jun; SAFINA, Brian; LI, Jun; CHABOT, Christine
Patent: WO2008/6032 A1, 2008 ;
Location in patent: Page/Page column 117 ;
WO 2008/006032 A1
反应条件
1: ethyl acetoacetate With sodium hydride in tetrahydrofuran
T=0°C; 0.333333 h;
2: With tert.-butyl lithium in tetrahydrofuran; pentane
T=0°C; 30 h;
3: iso-butyl iodide in tetrahydrofuran; pentane
Further stages.;
参考文献
Lager, Erik; Nilsson, Jakob; stergaard Nielsen, Elsebet; Nielsen, Mogens; Liljefors, Tommy; Sterner, Olov
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 14 p. 6936 - 6948
反应条件
toluene-4-sulfonic acid in benzene
2 h; Heating;
参考文献
Kanojia, Ramesh M.; Wachter, Michael P.; Levine, Seymour D.; Adams, Richard E.; Chen, R.; et al.
Journal of Organic Chemistry, 1982 , vol. 47, # 7 p. 1310 - 1319
反应条件
1: 1.) Mg, EtOH / 1.) CCl4, Et2O, reflux, 3 h, 2.) reflux, 1 h
2: 40 percent / p-TsOH*H2O / benzene / 2 h / Heating
View Scheme
参考文献
Kanojia, Ramesh M.; Wachter, Michael P.; Levine, Seymour D.; Adams, Richard E.; Chen, R.; et al.
Journal of Organic Chemistry, 1982 , vol. 47, # 7 p. 1310 - 1319
反应条件
sodium hydride in diethyl ether
Heating;
参考文献
Mikolajczak,K.L. et al.
Tetrahedron, 1972 , vol. 28, p. 1995 - 2001
反应条件
1: 4-methylpentanoic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran
Acylation;
2: malonic acid ethyl ester monopotassium salt With magnesium chloride in tetrahydrofuran
Substitution; decarboxylation;
参考文献
Boyd, Steven A.; Mantei, Robert A.; Tasker, Andrew S.; Liu, Gang; Sorensen, Bryan K.; Henry Jr., Kenneth J.; Von Geldern, Thomas W.; Winn, Martin; Wu-Wong, Jinshyun R.; Chiou, William J.; Dixon, Douglas B.; Hutchins, Charles W.; Marsh, Kennan C.; Nguyen, Bach; Opgenorth, Terry J.
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 6 p. 991 - 1002
反应条件
diethyl ether
anschliessend mit 10prozentig wss. Ammoniak;
参考文献
Koegl; Salemink
Recueil des Travaux Chimiques des Pays-Bas, 1952 , vol. 71, p. 779,785
