3-硝基-4-甲氧基苯胺合成路线 （共 25 条）
参考文献
Morton-Norwich Products, Inc.
Patent: US3947434 A1, 1976 ;
反应条件
hydrogenchloride; sodium azide; sodium nitrite in water
T=0°C;
参考文献
Odlo, Kristin; Fournier-Dit-Chabert, Jeremie; Ducki, Sylvie; Gani, Osman A.B.S.M.; Sylte, Ingebrigt; Hansen, Trond Vidar
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 18 p. 6874 - 6885
反应条件
1: potassium carbonate / 4 h / 150 °C
2: iron / acetic acid / 4 h / 90 °C
View Scheme
参考文献
VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;
反应条件
1: triethylamine / dichloromethane / 3 h / 20 °C / |Inert atmosphere
2: sodium hydroxide / water / 3 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Reddy, M. V. Ramana; Mallireddigari, Muralidhar R.; Pallela, Venkat R.; Cosenza, Stephen C.; Billa, Vinay K.; Akula, Balaiah; Subbaiah, D. R. C. Venkata; Bharathi, E. Vijaya; Padgaonkar, Amol; Lv, Hua; Gallo, James M.; Reddy, E. Premkumar
Journal of Medicinal Chemistry, 2013 , vol. 56, # 13 p. 5562 - 5586
反应条件
1: triethylamine / dichloromethane / 3 h / 20 °C / |Inert atmosphere
2: sodium hydroxide / water / 3 h / 20 °C / |Inert atmosphere
3: acetic acid; benzylamine / 8 h / 20 °C / |Reflux; |Inert atmosphere
4: sodium dithionite / water; acetone / 0.5 h / 50 °C / |Inert atmosphere
View Scheme
参考文献
Reddy, M. V. Ramana; Mallireddigari, Muralidhar R.; Pallela, Venkat R.; Cosenza, Stephen C.; Billa, Vinay K.; Akula, Balaiah; Subbaiah, D. R. C. Venkata; Bharathi, E. Vijaya; Padgaonkar, Amol; Lv, Hua; Gallo, James M.; Reddy, E. Premkumar
Journal of Medicinal Chemistry, 2013 , vol. 56, # 13 p. 5562 - 5586
