N-[(3-氨基甲酰苯并吡喃-2-亚基)氨基]吡啶-4-甲酰胺合成路线 （共 8 条）
反应条件
1: 1.) KH, 2.) FeCl3, NH3, Li / 1) THF, 1 h; 2) THF, -33 deg C, 55 min 2: 5 percent / diethyl ether; methanol View Scheme
参考文献
Mander, Lewis N.; Morris, Jonathan C.
Journal of Organic Chemistry, 1997 , vol. 62, # 21 p. 7497 - 7499
反应条件
potassium carbonate in acetone Heating;
参考文献
Horii,Z.-I. et al.
Chemical and Pharmaceutical Bulletin, 1971 , vol. 19, p. 1245 - 1256
反应条件
1: With potassium hydroxide; water in ethanol
72 h; Heating / reflux;
2: With hydrogenchloride in ethanol; water
pH=< 2;
参考文献
Jacobsen, Eric Jon; Myers, Jason K.; Walker, Daniel Patrick; Wishka, Donn G.; Reitz, Steven Charles; Piotrowski, David W.; Acker, Brad A.; Groppi JR., Vincent E.
Patent: US2003/236270 A1, 2003 ;
Location in patent: Page 39 ;
反应条件
1: aq. KOH
2: (i) EtMgBr, Et2O, benzene, (ii) /BRN= 1900390/
View Scheme
参考文献
Horii,Z.-I. et al.
Chemical and Pharmaceutical Bulletin, 1971 , vol. 19, p. 1245 - 1256
参考文献
Girardet
Helvetica Chimica Acta, 1931 , vol. 14, p. 513
参考文献
Adcock,W.; Wells,P.R.
Australian Journal of Chemistry, 1965 , vol. 18, p. 1351 - 1364
反应条件
(i) EtMgBr, Et2O, benzene, (ii) /BRN= 1900390/; Multistep reaction;
参考文献
Horii,Z.-I. et al.
Chemical and Pharmaceutical Bulletin, 1971 , vol. 19, p. 1245 - 1256
参考文献
Jacques
Bulletin de la Societe Chimique de France, 1953 , p. 857,862
