4-乙酰基-2,3,4,5-四氢-1H-1,4-苯并二氮杂卓合成路线 （共 12 条）
反应条件
potassium carbonate in acetonitrile T=0°C; 0.5 h;
参考文献
Wyeth
Patent: US2006/122385 A1, 2006 ;
Location in patent: Page/Page column 13-14 ;
反应条件
iron in dichloromethane T=20 - 45°C; 6.5 h;
参考文献
TOPHARMAN SHANGHAI CO., LTD.; WEIFANG TEHUA CHEMICAL CO., LTD.
Patent: US2010/256358 A1, 2010 ;
Location in patent: Page/Page column 5 ;
反应条件
triethylamine in dichloromethane T=20°C; Cooling with ice;
参考文献
Topharman Shanghai Co., Ltd.; Weifang Tehua Chemical Co., Ltd.
Patent: EP2163538 A1, 2010 ;
Location in patent: Page/Page column 8 ;
反应条件
iron; triethylamine in dichloromethane T=20 - 45°C; 9.5 h;
参考文献
Topharman Shanghai Co., Ltd.; Weifang Tehua Chemical Co., Ltd.
Patent: EP2163538 A1, 2010 ;
Location in patent: Page/Page column 8 ;
反应条件
triethylamine in dichloromethane T=20°C; Cooling with ice; Product distribution / selectivity;
参考文献
TOPHARMAN SHANGHAI CO., LTD.; WEIFANG TEHUA CHEMICAL CO., LTD.
Patent: US2010/256358 A1, 2010 ;
Location in patent: Page/Page column 5 ;
反应条件
iron; triethylamine in dichloromethane T=20 - 45°C; 8.5 h; Product distribution / selectivity;
参考文献
TOPHARMAN SHANGHAI CO., LTD.; WEIFANG TEHUA CHEMICAL CO., LTD.
Patent: US2010/256358 A1, 2010 ;
Location in patent: Page/Page column 5 ;
反应条件
pyridine in dichloromethane T=0 - 20°C;
参考文献
Zhao, Qingjie; Li, Haihong; Zhu, Fuqiang; Guo, Hongli; Shen, Jingshan
Organic Preparations and Procedures International, 2008 , vol. 40, # 5 p. 490 - 493
反应条件
1: pyridine / 24 h / Heating 2: acetic acid / 24 h 3: lithium aluminum hydride / tetrahydrofuran / 24 h 4: TEA / 24 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 10 p. 2603 - 2607
反应条件
1: lithium aluminum hydride / tetrahydrofuran / 24 h 2: TEA / 24 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 10 p. 2603 - 2607
反应条件
1: acetic acid / 24 h 2: lithium aluminum hydride / tetrahydrofuran / 24 h 3: TEA / 24 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 10 p. 2603 - 2607
