3,5,5-三甲基-2-吗啉酮合成路线 （共 9 条）
反应条件
(i) (irradiation), (ii) (heating); Multistep reaction;
参考文献
Koch,T.H. et al.
Journal of the American Chemical Society, 1975 , vol. 97, p. 7285 - 7288
反应条件
2,2',3,3'-tetrahydro-3,3'-dihydroxy-2,2'-dioxo-[3,3'-bi-1H-indole] in dimethylsulfoxide-d6
T=50°C; 65 h; Yield given. Title compound not separated from byproducts;
参考文献
Bennett, Richard W.; Wharry, Donald L.; Koch, Tad H.
Journal of the American Chemical Society, 1980 , vol. 102, # 7 p. 2345 - 2349
反应条件
tris(hydroxymethyl)methylamine hydrochloride; tri-(hydroxymethyl)-methylamine in methanol
24 h; Ambient temperature;
参考文献
Kleyer, Don L.; Gaudiano, Giorgio; Koch, Tad H.
Journal of the American Chemical Society, 1984 , vol. 106, # 4 p. 1105 - 1109
反应条件
tris(hydroxymethyl)methylamine hydrochloride; tri-(hydroxymethyl)-methylamine in methanol
参考文献
Kleyer, Don L.; Koch, Tad H.
Journal of the American Chemical Society, 1984 , vol. 106, # 8 p. 2380 - 2387
反应条件
1: CHCl3
2: 80 °C
View Scheme
参考文献
Burns, John M.; Wharry, Donald L.; Koch, Tad H.
Journal of the American Chemical Society, 1981 , vol. 103, # 4 p. 849 - 856
反应条件
T=80°C; Title compound not separated from byproducts;
参考文献
Burns, John M.; Wharry, Donald L.; Koch, Tad H.
Journal of the American Chemical Society, 1981 , vol. 103, # 4 p. 849 - 856
反应条件
Tris buffer in methanol
T=25°C; Rate constant;
参考文献
Mahoney, Robert Patrick; Fretwell, Paul A.; Demirdji, Samuel H.; Mauldin III; Benson Jr., Olester; Koch, Tad H.
Journal of the American Chemical Society, 1992 , vol. 114, # 1 p. 186 - 193
反应条件
hydrogenchloride; 7-deoxydaunomycinone; tri-(hydroxymethyl)-methylamine in methanol
24 h; Ambient temperaturesolvent dependence, deuterium kinetic isotope effect; MechanismRate constant;
参考文献
Kleyer, Don L.; Koch, Tad H.
Journal of the American Chemical Society, 1983 , vol. 105, # 18 p. 5911 - 5912
反应条件
Trizma-buffer in methanol
24 h; Ambient temperature;
参考文献
Kleyer, Don L.; Gaudiano, Giorgio; Koch, Tad H.
Journal of the American Chemical Society, 1984 , vol. 106, # 4 p. 1105 - 1109
