6-溴-1H-吡咯并[2,3-B]吡啶-2-甲酸乙酯合成路线 （共 5 条）
反应条件
1: With trifluoroacetic acid in dichloromethane T=0 - 20°C; 2.08333 h; 2: With sodium hydrogencarbonate in dichloromethane; water
参考文献
F. HOFFMANN-LA ROCHE AG; VERNALIS RESEARCH LIMITED
Patent: WO2005/849 A1, 2005 ;
Location in patent: Page/Page column 62 ;
反应条件
trifluoroacetic acid in dichloromethane T=0 - 20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1207 - 1211
反应条件
1: 99 percent / DMAP / acetonitrile / 20 °C 2: 60 percent / m-CPBA / CH2Cl2 / 20 °C 3: 76 percent / ethyl chloroformate; HMDS / tetrahydrofuran / 20 °C 4: TFA / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1207 - 1211
反应条件
1: 60 percent / m-CPBA / CH2Cl2 / 20 °C 2: 76 percent / ethyl chloroformate; HMDS / tetrahydrofuran / 20 °C 3: TFA / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1207 - 1211
反应条件
1: 76 percent / ethyl chloroformate; HMDS / tetrahydrofuran / 20 °C 2: TFA / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1207 - 1211
