4-(1H-吡咯并[2,3-B]吡啶-4-基)-1-哌嗪羧酸叔丁酯合成路线 （共 6 条）
反应条件
N-methyl-pyrrolidine
T=135°C; 72 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/94840 A1, 2006 ;
Location in patent: Page/Page column 45-46 ;
反应条件
1-methyl-pyrrolidin-2-one; triethylamine
T=160°C; 2 h; microwave irradiation;
参考文献
Caldwell, John J.; Cheung, Kwai-Ming; Collins, Ian
Tetrahedron Letters, 2007 , vol. 48, # 9 p. 1527 - 1529
反应条件
1.1: 99 percent / NaH / tetrahydrofuran / Heating
2.1: n-butyllithium / diethyl ether / -78 °C
2.2: 71 percent / N-fluorobenzenesulfonimide / tetrahydrofuran / -78 °C
3.1: 24 percent / triethylamine; NMP / 2 h / 160 °C / microwave irradiation
View Scheme
参考文献
Caldwell, John J.; Cheung, Kwai-Ming; Collins, Ian
Tetrahedron Letters, 2007 , vol. 48, # 9 p. 1527 - 1529
反应条件
1.1: n-butyllithium / diethyl ether / -78 °C
1.2: 71 percent / N-fluorobenzenesulfonimide / tetrahydrofuran / -78 °C
2.1: 24 percent / triethylamine; NMP / 2 h / 160 °C / microwave irradiation
View Scheme
参考文献
Caldwell, John J.; Cheung, Kwai-Ming; Collins, Ian
Tetrahedron Letters, 2007 , vol. 48, # 9 p. 1527 - 1529
反应条件
1.1: AcCl; NaI / acetonitrile / Heating
1.2: 52 percent / aq. NaOH / tetrahydrofuran / 40 °C
2.1: 99 percent / NaH / tetrahydrofuran / Heating
3.1: n-butyllithium / diethyl ether / -78 °C
3.2: 71 percent / N-fluorobenzenesulfonimide / tetrahydrofuran / -78 °C
4.1: 24 percent / triethylamine; NMP / 2 h / 160 °C / microwave irradiation
View Scheme
参考文献
Caldwell, John J.; Cheung, Kwai-Ming; Collins, Ian
Tetrahedron Letters, 2007 , vol. 48, # 9 p. 1527 - 1529
反应条件
1.1: n-butyllithium / diethyl ether / -78 °C
1.2: 66 percent / N-fluorobenzenesulfonimide / tetrahydrofuran / -78 °C
2.1: 24 percent / triethylamine; NMP / 2 h / 160 °C / microwave irradiation
View Scheme
参考文献
Caldwell, John J.; Cheung, Kwai-Ming; Collins, Ian
Tetrahedron Letters, 2007 , vol. 48, # 9 p. 1527 - 1529
