1.1: n-butyllithium / tetrahydrofuran / 1 h / -10 - -5 °C / |Inert atmosphere 1.2: 1 h / -10 - -5 °C 2.1: copper(l) iodide / N,N-dimethyl-formamide / 12 h / 60 - 70 °C 3.1: hydrogenchloride / water; dichloromethane / 4 h / 20 °C View Scheme

hydrogenchloride; aluminium trichloride; benzene anschliessend Hydrolyse;

Behandeln des Reaktionsgemisches mit Wasser;

Behandeln des Reaktionsgemisches mit Wasser;

1: 98 percent / sodium chlorite, dibasic sodium phosphate, 2-methyl-2-butene / 2-methyl-propan-2-ol; H2O / 0.5 h / Ambient temperature 2: 85 percent / nitric acid / 0.17 h / 0 °C 3: 95 percent / hydrogen / platinum oxide / 2 h / 2068.6 Torr 4: 78 percent / sodium hydroxide / toluene / 0 °C 5: 88 percent / sodium hydride / N,N-dimethyl-acetamide / 1.) RT, 12 h, 2.) 30 min 6: diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 1.) -78 deg C, 90 min, 2.) RT, 90 min 7: 28 percent / palladium-on-charcoal / xylene / 1 h / Heating View Scheme

sodium chlorite; disodium hydrogenphosphate; 2-methyl-but-2-ene in water; tert-butyl alcohol 0.5 h; Ambient temperature;

1: 98 percent / H2 / 5percent Pd-C / ethanol 2: 99 percent / H2 / 5percent Pd-C / ethanol 3: 78 percent / 6N HCl 4: 99 percent / CH2Cl2 / 1 h / Ambient temperature 5: 95 percent / H2 / 5percent Pd-C / ethanol / 7 h / 50 °C View Scheme

1: 98 percent / H2 / 5percent Pd-C / ethanol 2: 99 percent / H2 / 5percent Pd-C / ethanol 3: 1) 6N HCl, 2) H2 / 2) 5percent Pd-C / 1) 25 deg C, 24h, 2) r.t., 1 atm View Scheme

1: 98 percent / H2 / 5percent Pd-C / methanol / 2 h / Ambient temperature 2: 1) 6N HCl, 2) H2 / 2) 5percent Pd-C / 1)r.t., 4 d, 2) r.t. View Scheme