5-羟基-2-甲基苯甲酸合成路线 （共 26 条）
反应条件
potassium hydroxide T=250°C;
参考文献
Pharmaceutical Bulletin, , vol. 2, p. 359,365
反应条件
sodium hydroxide T=260°C; unter Druck;
参考文献
DE91201 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 4, p. 148
反应条件
sodium hydroxide T=260°C; unter Druck;
参考文献
DE91201 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 4, p. 148
反应条件
1.1: palladium on activated charcoal; hydrogen / ethyl acetate / 20 °C 2.1: sulfuric acid; sodium nitrite / water / 0.5 h / 0 °C 2.2: 0.5 h / |Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 21 p. 8561 - 8578
参考文献
DE91201 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 4, p. 149
参考文献
Chemische Berichte, , vol. 14, p. 40
参考文献
Chemische Berichte, , vol. 16, p. 1959
Chemische Berichte, , vol. 17, p. 164
反应条件
potassium hydroxide in water 16 h; Reflux;
参考文献
Herzog, Beat; Neier, Reinhard
Arkivoc, 2011 , vol. 2011, # 6 p. 29 - 44
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 70 °C 2: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / tetrachloromethane / 3 h / 72 °C View Scheme
参考文献
Baur, Benjamin; Storch, Kirsten; Martz, Kathrin E.; Goettert, Marcia I.; Richters, Andre; Rauh, Daniel; Laufer, Stefan A.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8561 - 8578
反应条件
1: With sulfuric acid 3 h; Reflux; 2: With sodium hydroxide in methanol pH=7;
参考文献
BIOGEN IDEC MA INC; PENG, Hairuo; CUERVO, Julio, H.; ISHCHENKO, Alexey; KUMARAVEL, Gnanasambandam; LEE, Wen-cherng; LUGOVSKOY, Alexey; TALREJA, Tina; TAVERAS, Arthur, G.; XIN, Zhili
Patent: WO2010/138901 A1, 2010 ;
Location in patent: Page/Page column 171-172 ;
WO 2010/138901 A1
