4-羟基-2-甲基苯甲酸合成路线 （共 37 条）
反应条件
1: sulfuric acid / 1,4-dioxane / 60 h / 20 °C / |Cooling; |High pressure
2: 1,3-dibromo-5,5-dimethyl-hydantoin; dibenzoyl peroxide / tetrachloromethane / 0.5 h / 90 °C / |Inert atmosphere
3: silver nitrate / 1,4-dioxane; water / 72 h / 20 °C
4: hydrogenchloride / diethyl ether
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; WALSH, Shawn; PASTERNAK, Alexander; CATO, Brian; FINKE, Paul, E.; FRIE, Jessica; FU, Qinghong; KIM, Dooseop; PIO, Barbara; SHAHRIPOUR, Aurash; SHI, Zhi-Cai; TANG, Haifeng
Patent: WO2013/39802 A1, 2013 ;
参考文献
Cooper, Lori L.; Samulski, Edward T.; Scharrer, Eric
Molecular Crystals and Liquid Crystals, 2009 , vol. 511, p. 2031673 - 2171687
反应条件
thionyl chloride in methanol; water; ethyl acetate
参考文献
AJINOMOTO CO. INC.
Patent: US2012/59149 A1, 2012 ;
反应条件
thionyl chloride
T=0 - 60°C;
参考文献
Ajinomoto Co., Inc.; TAKAHASHI, Daisuke
Patent: EP2612845 A1, 2013 ;
Location in patent: Paragraph 0269; 0270 ;
反应条件
1: With potassium hydrogencarbonate in N,N-dimethyl-formamide
T=20 - 40°C; 3 h;
2: With water in N,N-dimethyl-formamide
T=40°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/157330 A1, 2008 ;
Location in patent: Page/Page column 83 ;
反应条件
in diethyl ether
T=20°C;
参考文献
Sebej, Peter; Lim, Bum Hee; Park, Bong Ser; Givens, Richard S.; Klan, Petr
Organic Letters, 2011 , vol. 13, # 4 p. 644 - 647
反应条件
1.1: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C
2.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 1.33 h / 0 - 20 °C
2.2: 0 °C
View Scheme
参考文献
ARAGON PHARMACEUTICALS, INC.; KAHRAMAN, Mehmet; GOVEK, Steven, P.; NAGASAWA, Johnny, Y.; SMITH, Nicholas, D.
Patent: WO2011/156518 A2, 2011 ;
WO 2011/156518 A2
