反应条件
1: AlCl3
2: Zn/HCl
3: CF3COOH, (CF3COO)2O
4: 2.) 10percent HCl / 1.) Et2O, reflux, 4 h, 2.) CH2Cl2
5: 1.) N-methylmorpholine N-oxide, OsO4, 2.) sodium dithionite, 3.) 6N HCl / 1.) Me2CO, t-BuOH, 2 d, 2.) 1 h, 3.) CH2Cl2
6: 55 percent / Pd/C / 1,3,5-trimethyl-benzene / 3 h / Heating
7: 89 percent / Zr(acac)2, TBHP / CH2Cl2
8: 98 percent / pyridine / CH2Cl2 / 18 h / 20 °C
9: 66 percent / CuCN, BF3*Et2O / tetrahydrofuran; diethyl ether / 8 h / -78 - 20 °C
View Scheme
参考文献
Krohn, Karsten; Zimmermann, Gregor
Journal of Organic Chemistry, 1998 , vol. 63, # 12 p. 4140 - 4142
