4-甲基-1-哌嗪乙酸甲酯合成路线 （共 4 条）
反应条件
in dichloromethane methylalcohol; ethyl acetate
参考文献
SmithKline Beckman Corporation
Patent: US4761415 A1, 1988 ;
反应条件
1: 1-methyl-piperazine With potassium carbonate in tetrahydrofuran T=20°C; 0.25 h; Inert atmosphere; 2: bromoacetic acid methyl ester in tetrahydrofuran T=20°C; Inert atmosphere;
参考文献
Sohn, Chang Ho; Lee, J. Eugene; Sweredoski, Michael J.; Graham, Robert L.J.; Smith, Geoffrey T.; Hess, Sonja; Czerwieniec, Gregg; Loo, Joseph A.; Deshaies, Raymond J.; Beauchamp
Journal of the American Chemical Society, 2012 , vol. 134, # 5 p. 2672 - 2680
反应条件
1: With potassium hydroxide in tetrahydrofuran T=20°C; 10 h; 2: With hydrogenchloride in water
参考文献
Sohn, Chang Ho; Lee, J. Eugene; Sweredoski, Michael J.; Graham, Robert L.J.; Smith, Geoffrey T.; Hess, Sonja; Czerwieniec, Gregg; Loo, Joseph A.; Deshaies, Raymond J.; Beauchamp
Journal of the American Chemical Society, 2012 , vol. 134, # 5 p. 2672 - 2680
反应条件
hydrogen fluoride
T=7 - 8°C; Simons fluorination; 10.1 h; Electrochemical reaction; Further byproducts given;
参考文献
Abe, Takashi; Baba, Hajime; Fukaya, Haruhiko; Tamura, Masanori; Sekiya, Akira
Journal of Fluorine Chemistry, 2003 , vol. 119, # 1 p. 27 - 38
