5-氯-4-硝基噻吩-2-羧酸甲酯合成路线 （共 7 条）
反应条件
nitric acid T=0°C; 1 h;
参考文献
Japan Tobacco Inc.
Patent: EP1688420 A1, 2006 ;
Location in patent: Page/Page column 122 ;
反应条件
2: sulfuric acid; nitric acid View Scheme
参考文献
Journal of the American Chemical Society, , vol. 74, p. 2965,2969
反应条件
in methanol T=20°C; ΔH(excit.), ΔS(excit.); Rate constantThermodynamic data;
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , # 10 p. 2187 - 2190
参考文献
Hurd; Kreuz
Journal of the American Chemical Society, 1952 , vol. 74, p. 2965,2969
反应条件
1: 67 percent / Fe / acetic acid / 75 - 80 °C 2: conc. HCl / Heating 3: diethyl ether / Ambient temperature View Scheme
参考文献
Gol'dfarb, Ya. L.; Bulgakova, V. N.; Fabrichnyi, B. P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 12 p. 1283 - 1286
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 12 p. 1626 - 1629
反应条件
iron in acetic acid
T=75 - 80°C;
参考文献
Gol'dfarb, Ya. L.; Bulgakova, V. N.; Fabrichnyi, B. P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 12 p. 1283 - 1286
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 12 p. 1626 - 1629
反应条件
1: 67 percent / Fe / acetic acid / 75 - 80 °C
2: conc. HCl / Heating
View Scheme
参考文献
Gol'dfarb, Ya. L.; Bulgakova, V. N.; Fabrichnyi, B. P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 12 p. 1283 - 1286
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 12 p. 1626 - 1629
