sodium hydroxide in water 1.5 h; Heating;

1: 81 percent / xylene / 16 h / Heating 2: 1.) NaOMe, 2.) H2 / 2.) 5percent Pd/C / 1.) DMF, room temperature, 5 h, 2.) MeOH, atmospheric pressure, room temperature, 16 h 3: 90 percent / NaOH / H2O / 1.5 h / Heating View Scheme

1: 1.) POCl3 / 1.) 0 deg C, 1 h, 2.) DMF, a) 0-5 deg C, b) room temperature, 3 h 2: 1.) NaOMe, 2.) H2 / 2.) 5percent Pd/C / 1.) DMF, room temperature, 5 h, 2.) MeOH, atmospheric pressure, room temperature, 16 h 3: 90 percent / NaOH / H2O / 1.5 h / Heating View Scheme

1: 72 percent / benzoyl peroxide / 4 h / 90 - 92 °C 2: 60 percent / silica-magnesia / 250 - 260 °C 3: 1.) POCl3 / 1.) 0 deg C, 1 h, 2.) DMF, a) 0-5 deg C, b) room temperature, 3 h 4: 1.) NaOMe, 2.) H2 / 2.) 5percent Pd/C / 1.) DMF, room temperature, 5 h, 2.) MeOH, atmospheric pressure, room temperature, 16 h 5: 90 percent / NaOH / H2O / 1.5 h / Heating View Scheme

1: 1.) NaOMe, 2.) H2 / 2.) 5percent Pd/C / 1.) DMF, room temperature, 5 h, 2.) MeOH, atmospheric pressure, room temperature, 16 h 2: 90 percent / NaOH / H2O / 1.5 h / Heating View Scheme

1: 60 percent / silica-magnesia / 250 - 260 °C 2: 1.) POCl3 / 1.) 0 deg C, 1 h, 2.) DMF, a) 0-5 deg C, b) room temperature, 3 h 3: 1.) NaOMe, 2.) H2 / 2.) 5percent Pd/C / 1.) DMF, room temperature, 5 h, 2.) MeOH, atmospheric pressure, room temperature, 16 h 4: 90 percent / NaOH / H2O / 1.5 h / Heating View Scheme