6-异丙基-2-氧代-1,2-二氢-3-吡啶甲腈合成路线 （共 15 条）
反应条件
1: in water T=20°C; 0.166667 h; 2: With piperidine; acetic acid in water 2 h; Heating / reflux; 3: With acetic acid in water pH=4;
参考文献
ABBOTT LABORATORIES
Patent: WO2007/76034 A2, 2007 ;
Location in patent: Page/Page column 75-76 ;
反应条件
1: 1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile With lithium diisopropyl amide in tetrahydrofuran T=-78 - 0°C; 2 h; 2: methyl iodide in tetrahydrofuran T=20°C; 18 h;
参考文献
US6350764 B2, ;
Page column 86 ;
反应条件
piperidine; acetic acid in water 2 h; Reflux;
参考文献
WO2012/171337 A1, ;
Page/Page column 111 ;
WO 2012/171337 A1
反应条件
in ethanol T=80°C; Cyclization; addition; elimination; Dimroth rearrangement; 120 h;
参考文献
Alberola, Angel; Calvo, Luis A.; Ortega, Alfonso Gonzalez; Ruiz, M. Carmen Sanudo; Yustos, Pedro; Granda, Santiago Garcia; Garcia-Rodriguez, Esther
Journal of Organic Chemistry, 1999 , vol. 64, # 26 p. 9493 - 9498
反应条件
in ethanol T=80°C; Cyclization; addition; elimination; Dimroth rearrangement; 120 h;
参考文献
Alberola, Angel; Calvo, Luis A.; Ortega, Alfonso Gonzalez; Ruiz, M. Carmen Sanudo; Yustos, Pedro; Granda, Santiago Garcia; Garcia-Rodriguez, Esther
Journal of Organic Chemistry, 1999 , vol. 64, # 26 p. 9493 - 9498
反应条件
copper in quinoline 2 h; Heating;
参考文献
Mosti; Menozzi; Schenone; Dorigo; Gaion; Benetollo; Bombieri
European Journal of Medicinal Chemistry, 1989 , vol. 24, # 5 p. 517 - 529
反应条件
1: 71 percent / sodium ethoxide / toluene / 70 °C 2: 44 percent / pyridinium 4-toluenesulfonate / 72 h / Heating 3: HCl / H2O View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 26 p. 9493 - 9498
反应条件
1: 87 percent / NaOEt / ethanol / 24 h / Ambient temperature 2: 93 percent / KOH / aq. ethanol / 4 h / Heating 3: 50 percent / copper powder / quinoline / 2 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 24, # 5 p. 517 - 529
反应条件
1: 93 percent / KOH / aq. ethanol / 4 h / Heating 2: 50 percent / copper powder / quinoline / 2 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 24, # 5 p. 517 - 529
反应条件
1: 3-methyl-butan-2-one; formic acid ethyl ester With sodium in diethyl ether T=0 - 25°C; 18 h; 2: 2-cyano-acetamide With piperidinyl acetate in diethyl ether; water 2 h; Reflux;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 6 p. 2212 - 2215
