6-异丙基-2-氧代-1,2-二氢-3-吡啶甲腈合成路线 （共 15 条）
反应条件
1: N,N-dimethyl-formamide / 100 °C 2: piperidine; acetic acid / water / 2 h / Reflux View Scheme
参考文献
WO2012/171337 A1, ;
WO 2012/171337 A1
反应条件
1: 3-methyl-butan-2-one; formic acid ethyl ester With sodium methylate in diethyl ether 2: 1-cyanoformamide With piperidinium acetate 16 h;
参考文献
Fischer, Christian B.; Polborn, Kurt; Steininger, Harald; Zipse, Hendrik
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2004 , vol. 59, # 10 p. 1121 - 1131
反应条件
trichlorophosphate 2 h; Heating / reflux;
参考文献
Nishikawa; Shindo; Ishii; Nakamura; Kon; Uno
Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 583 - 593
参考文献
Kotschetkow
Doklady Akademii Nauk SSSR, 1952 , vol. 84, p. 289,292
Chem.Abstr., 1953 , p. 3309
反应条件
phosphorus pentachloride T=120°C; Erhitzen des erhaltenen Nitrils mit wss. H2SO4 und Erwaermen des Reaktionsprodukts mit Aethanol und H2SO4;
参考文献
Sperber et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 704,707
