2-(4-甲氧基苯基)-1H-吲哚合成路线 （共 67 条）
反应条件
2: copper oxide / chromium oxide catalyst / 500 - 525 °C
View Scheme
参考文献
Hansch et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 704
反应条件
1: ortho-N-trimethylsilyl-toluidine With n-butyllithium in hexane
Heating;
2: methyl 4-(N-tert-butoxycarbonyl-(5S)-methyl-(2S)-pyrrolidinylmethoxy)benzoate in hexane
7 h; Heating; Further stages.;
参考文献
Mahboobi, Siavosh; Eichhorn, Emerich; Winkler, Matthias; Sellmer, Andreas; Moellmann, Ute
European Journal of Medicinal Chemistry, 2008 , vol. 43, # 3 p. 633 - 656
反应条件
1: 95 percent / Zn, HBr / ethanol
2: NEt3 / CH2Cl2; toluene
3: 85 percent / MeONa / toluene / Heating
View Scheme
参考文献
Corre, Maurice Le; Hercouet, Alain; Baron, Henri Le
Journal of the Chemical Society, Chemical Communications, 1981 , # 1 p. 14 - 15
反应条件
1: NEt3 / CH2Cl2; toluene
2: 85 percent / MeONa / toluene / Heating
View Scheme
参考文献
Corre, Maurice Le; Hercouet, Alain; Baron, Henri Le
Journal of the Chemical Society, Chemical Communications, 1981 , # 1 p. 14 - 15
反应条件
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 2 h / Inert atmosphere; Reflux
2: NaAuCl4 / isopropyl alcohol / 3 h / 20 °C
View Scheme
参考文献
Brand, Jonathan P.; Chevalley, Clara; Waser, Jerome
Beilstein Journal of Organic Chemistry, 2011 , vol. 7, art. no. A65, p. 565 - 569
反应条件
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 2 h / Inert atmosphere; Reflux
2: NaAuCl4 / isopropyl alcohol / 3 h / 20 °C
View Scheme
参考文献
Brand, Jonathan P.; Chevalley, Clara; Waser, Jerome
Beilstein Journal of Organic Chemistry, 2011 , vol. 7, art. no. A65, p. 565 - 569
反应条件
1: sodium sulfite / water / 5 h / 70 - 80 °C
2: palladium dichloride; silver(I) acetate; sulfuric acid / N,N-dimethyl-formamide; acetonitrile / 0.67 h / 100 °C / |Sealed tube; |Microwave irradiation
View Scheme
参考文献
Miao, Tao; Li, Pinhua; Wang, Guan-Wu; Wang, Lei
Chemistry - An Asian Journal, 2013 , vol. 8, # 12 p. 3185 - 3190
反应条件
boron trifluoride diethyl etherate
T=175 - 200°C;
参考文献
Blades; Wilds
Journal of Organic Chemistry, 1956 , vol. 21, p. 1013,1021
反应条件
PPA
T=100 - 120°C; 1 h;
参考文献
Fusco, R.; Sannicolo, F.
Journal of Organic Chemistry, 1981 , vol. 46, # 1 p. 83 - 89
反应条件
1: 94 percent / Et3N / CH2Cl2 / 12 h / 20 °C
2: DMSO; Ac2O / 0 - 20 °C
3: 35 percent / PPh3; Zn / CH2Cl2 / 12 h / 20 °C
4: 52 percent / Pd2(dba)3; dppf; Et3N / toluene / 12 h / 100 °C
5: 100 percent / NaOH / ethanol; H2O / 0.17 h / 70 °C
View Scheme
参考文献
Thielges, Sabine; Meddah, Emilie; Bisseret, Philippe; Eustache, Jacques
Tetrahedron Letters, 2004 , vol. 45, # 5 p. 907 - 910
