2-(4-甲氧基苯基)-1H-吲哚合成路线 （共 67 条）
反应条件
1: 35 percent / PPh3; Zn / CH2Cl2 / 12 h / 20 °C
2: 52 percent / Pd2(dba)3; dppf; Et3N / toluene / 12 h / 100 °C
3: 100 percent / NaOH / ethanol; H2O / 0.17 h / 70 °C
View Scheme
参考文献
Thielges, Sabine; Meddah, Emilie; Bisseret, Philippe; Eustache, Jacques
Tetrahedron Letters, 2004 , vol. 45, # 5 p. 907 - 910
反应条件
1: DMSO; Ac2O / 0 - 20 °C
2: 35 percent / PPh3; Zn / CH2Cl2 / 12 h / 20 °C
3: 52 percent / Pd2(dba)3; dppf; Et3N / toluene / 12 h / 100 °C
4: 100 percent / NaOH / ethanol; H2O / 0.17 h / 70 °C
View Scheme
参考文献
Thielges, Sabine; Meddah, Emilie; Bisseret, Philippe; Eustache, Jacques
Tetrahedron Letters, 2004 , vol. 45, # 5 p. 907 - 910
反应条件
1: 52 percent / Pd2(dba)3; dppf; Et3N / toluene / 12 h / 100 °C
2: 100 percent / NaOH / ethanol; H2O / 0.17 h / 70 °C
View Scheme
参考文献
Thielges, Sabine; Meddah, Emilie; Bisseret, Philippe; Eustache, Jacques
Tetrahedron Letters, 2004 , vol. 45, # 5 p. 907 - 910
反应条件
1: N-bromosuccinimide (NBS), peroxyde de benzoyle / CCl4
2: 69 percent / toluene / 1.) 3h, RT, 2.) 2h, reflux
3: 94 percent / 48percent HBr, Zn / ethanol / 2 h / Heating
4: 93 percent / pyridine / CH2Cl2 / 0.5 h / Heating
5: 85 percent / t-BuOK / toluene / 0.25 h / Heating
View Scheme
参考文献
Corre, M. Le; Hercouet, A.; Stanc, Y. Le; Baron, H. Le
Tetrahedron, 1985 , vol. 41, # 22 p. 5313 - 5320
反应条件
1: 69 percent / toluene / 1.) 3h, RT, 2.) 2h, reflux
2: 94 percent / 48percent HBr, Zn / ethanol / 2 h / Heating
3: 93 percent / pyridine / CH2Cl2 / 0.5 h / Heating
4: 85 percent / t-BuOK / toluene / 0.25 h / Heating
View Scheme
参考文献
Corre, M. Le; Hercouet, A.; Stanc, Y. Le; Baron, H. Le
Tetrahedron, 1985 , vol. 41, # 22 p. 5313 - 5320
反应条件
trifluoroacetic acid in 1,2-dichloro-ethane
Reflux;
参考文献
Wang, Honggen; Liu, Lanying; Wang, Yong; Peng, Changlan; Zhang, Jiancun; Zhu, Qiang
Tetrahedron Letters, 2009 , vol. 50, # 49 p. 6841 - 6843
反应条件
tetrakis(triphenylphosphine) palladium(0); tert.-butyl lithium; zinc(II) chloride
Yield given. Multistep reaction;
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Takazawa, Nobuo; Yamanaka, Hiroshi
Heterocycles, 1993 , vol. 36, # 5 p. 941 - 942
反应条件
N,N-dimethyl-aniline
T=170°C;
参考文献
Nyerges, Miklos; Pinter, Aron; Viranyi, Andrea; Bitter, Istvan; Toke, Laszlo
Tetrahedron Letters, 2005 , vol. 46, # 3 p. 377 - 380
反应条件
1: 49.6 percent / sodium hydroxide / ethanol / 0.5 h / 80 °C
2: diethyl ether / 2 h / 20 °C
View Scheme
参考文献
Ding, Hua-Sheng; Yang, Chun-Hao; Xie, Yu-Yuan
Synthetic Communications, 2005 , vol. 35, # 20 p. 2625 - 2632
反应条件
1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 10 h / 20 - 40 °C / |Inert atmosphere; |Schlenk technique
2: Au/Carbon G-60 catalyst / toluene / 48 h / 90 °C / |Inert atmosphere; |Schlenk technique
View Scheme
参考文献
Perea-Buceta, Jesus E.; Wirtanen, Tom; Laukkanen, Otto-Ville; Maekelae, Mikko K.; Nieger, Martin; Melchionna, Michele; Huittinen, Nina; Lopez-Sanchez, Jose A.; Helaja, Juho
Angewandte Chemie - International Edition, 2013 , vol. 52, # 45 p. 11835 - 11839
Angew. Chem., 2013 , vol. 125, # 45 p. 12051 - 12055,5
