N,N-二甲基-5,6,7,8-四氢吡啶并[4,3-d]嘧啶-2-胺合成路线 (共 5 条)
反应条件
1: With trifluoroacetic acid in dichloromethane
T=0 - 20°C; 1 h;
2: in methanol
参考文献
GRUENENTHAL GmbH
Patent: US2012/71461 A1, 2012 ;
Location in patent: Page/Page column 137 ;
反应条件
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 - 20 °C
2.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / 130 °C / Microwave irradiation
3.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C
3.2: Amberlyst A-21
View Scheme
参考文献
GRUENENTHAL GmbH
Patent: US2012/71461 A1, 2012 ;
反应条件
1.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / 130 °C / Microwave irradiation
2.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C
2.2: Amberlyst A-21
View Scheme
参考文献
GRUENENTHAL GmbH
Patent: US2012/71461 A1, 2012 ;
反应条件
1.1: sodium hydroxide / water / 1 h / 80 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 - 20 °C
3.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / 130 °C / Microwave irradiation
4.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C
4.2: Amberlyst A-21
View Scheme
参考文献
GRUENENTHAL GmbH
Patent: US2012/71461 A1, 2012 ;
反应条件
1.1: 6 h / Reflux
2.1: sodium hydroxide / water / 1 h / 80 °C
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 - 20 °C
4.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / 130 °C / Microwave irradiation
5.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C
5.2: Amberlyst A-21
View Scheme
参考文献
GRUENENTHAL GmbH
Patent: US2012/71461 A1, 2012 ;