[(1R)-1-(4-溴苯基)乙基]氨基甲酸叔丁酯合成路线 (共 4 条)
反应条件
sodium hydrogencarbonate in methanol 4 h;
参考文献
N.V. Organon; Pharmacopeia Drug Discovery Inc.
Patent: US2007/149577 A1, 2007 ;
Location in patent: Page/Page column 6-7 ;
反应条件
triethylamine in acetonitrile T=20°C; 18 h;
参考文献
WO2009/36996 A2, ;
Page/Page column 74 ;
WO 2009/036996 A2
反应条件
triethylamine in dichloromethane T=20°C; 1.16667 h;
参考文献
Sanderson, John M.; Findlay, John B. C.; Fishwick, Colin W. G.
Tetrahedron, 2005 , vol. 61, # 47 p. 11244 - 11252
反应条件
1: in N,N-dimethyl-formamide 1 h; 2: With tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=70 - 75°C; 20.5 h;
参考文献
PFIZER INC.
Patent: WO2009/60278 A1, 2009 ;
Location in patent: Page/Page column 48 ;