1: With sodium ethanolate in ethanol
T=20°C;
2: With hydrogenchloride in water
T=100°C; pH=3; 0.0833333 - 0.166667 h;
参考文献
Ruah, Sara S. Hadida; Hazlewood, Anna R.; Grootenhuis, Peter D. J.; Singh, Ashvani Kumar; Cleveland, Thomas; Van-Goor, Frederick F.
Patent: US2007/105833 A1, 2007 ;
Location in patent: Page/Page column 49-50 ;
1.1: copper(ll) bromide / chloroform; ethyl acetate / 0.33 h / Reflux; Inert atmosphere
2.1: triethylamine / toluene / 20 °C
3.1: methanol; water / 1 h / 20 °C
3.2: 20 °C / pH 7 - 8
4.1: dichloromethane / Reflux; Inert atmosphere
View Scheme
参考文献
Carter, Rachel H.; Garson, Mary J.; Hill, Robert A.; Staunton, James; Sunter, David C.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 471 - 479