1: SOCl2, DMF / CHCl3 / Heating
2: CH2Cl2 / 18 h / Ambient temperature
View Scheme
参考文献
Cipollina, Joseph A.; Ruediger, Edward H.; New, James S.; Wire, Mary E.; Shepherd, Timothy A.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3316 - 3328
1: 95 percent / thionyl chloride / 18 h / 20 °C
2: CH2Cl2 / 2 h / 20 °C
3: thionyl chloride / 1 h / 25 °C
4: tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Carini, David J.; Duncia, John V.; Aldrich, Paul E.; Chiu, Andrew T.; Johnson, Alexander L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2525 - 2547
N-iodo-succinimide; perchloric acid in acetic acid
T=35°C; Rate constantProduct distributionMechanism;
参考文献
Radhakrishnamurti, P. S.; Panda, B. K.
Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical, 1983 , vol. 22, # 9 p. 770 - 773
Paulis, Tomas de; Janowsky, Aaron; Kessler, Robert M.; Clanton, Jeffrey A.; Smith, Howard E.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 10 p. 2027 - 2033