3-(2,3-二氯苯基)丙酸合成路线 （共 7 条）
反应条件
methanol; magnesium
T=20°C; 72 h; Cooling with ice;
参考文献
Okano, Akihiro; Ohkouchi, Munetaka
Patent: US2012/220772 A1, 2012 ;
Location in patent: Page/Page column 60 ;
反应条件
sodium borohydride in methanol
参考文献
Rhone-Poulenc Rorer S.A.
Patent: US5677306 A1, 1997 ;
反应条件
sodium hydroxide
2 h; Heating; Yield given;
参考文献
Bondinell; Chapin; Girard; Kaiser; Krog; Pavloff; Schwartz; Silvestri; Vaidya; Lam; Wellman; Pendleton
Journal of Medicinal Chemistry, 1980 , vol. 23, # 5 p. 506 - 511
反应条件
1: 1.) NaNO2, 48percent HBr, 2.) CuBr / 1.) acetone, H2O, -5 deg C, 30 min, 2.) acetone, H2O, 25 deg C, 30 min
2: Zn, acetic acid / 0.5 h
3: 10percent aq. NaOH / 2 h / Heating
View Scheme
参考文献
Bondinell; Chapin; Girard; Kaiser; Krog; Pavloff; Schwartz; Silvestri; Vaidya; Lam; Wellman; Pendleton
Journal of Medicinal Chemistry, 1980 , vol. 23, # 5 p. 506 - 511
反应条件
1: Zn, acetic acid / 0.5 h
2: 10percent aq. NaOH / 2 h / Heating
View Scheme
参考文献
Bondinell; Chapin; Girard; Kaiser; Krog; Pavloff; Schwartz; Silvestri; Vaidya; Lam; Wellman; Pendleton
Journal of Medicinal Chemistry, 1980 , vol. 23, # 5 p. 506 - 511
反应条件
1: SOCl2, DMF / toluene / 2.5 h / 55 - 60 °C
2: NaN3 / acetone; H2O / 0.17 h / 0 °C
3: toluene / 0.5 h / Heating
4: AlCl3 / tetrachloroethene / 3 h / 70 - 75 °C
5: 1M BH3 / tetrahydrofuran / 18 h / Heating
View Scheme
参考文献
Bondinell; Chapin; Girard; Kaiser; Krog; Pavloff; Schwartz; Silvestri; Vaidya; Lam; Wellman; Pendleton
Journal of Medicinal Chemistry, 1980 , vol. 23, # 5 p. 506 - 511
反应条件
1: With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=20°C; 4 h;
2: With AlCl3, aluminium chloride in 1,2-dichloro-ethane
1 h; Reflux;
参考文献
Okano, Akihiro; Ohkouchi, Munetaka
Patent: US2012/220772 A1, 2012 ;
Location in patent: Page/Page column 60-61 ;
