2-氨基-5-溴苯甲酸合成路线 （共 139 条）
反应条件
1: 78.5 percent / 2 h / 180 - 210 °C 2: 95.2 percent / POCl3, N,N-dimethylaniline / Heating View Scheme
参考文献
Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807
反应条件
1: triethylamine / tetrahydrofuran; water / 3 h / 20 °C / |Inert atmosphere 2: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
Kuznetsov, Alexey; Makarov, Anton; Rubtsov, Aleksandr E.; Butin, Alexander V.; Gevorgyan, Vladimir
Journal of Organic Chemistry, 2013 , vol. 78, # 23 p. 12144 - 12153
反应条件
hydrogenchloride; sulfur; sodium sulfide; sodium hydroxide; acetic acid; zinc; sodium nitrite 1.) H2O, 5 deg C, 2.) 5 deg C, 24 h, 3.) reflux, 48 h; Multistep reaction;
参考文献
Sugiyama, Hideyuki; Yoshida, Masato; Mori, Kouji; Kawamoto, Tomohiro; Sogabe, Satoshi; Takagi, Terufumi; Oki, Hideyuki; Tanaka, Toshimasa; Kimura, Hiroyuki; Ikeura, Yoshinori
Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 4 p. 613 - 624
反应条件
in N,N-dimethyl-formamide 16 h; Heating / reflux;
参考文献
WO2008/23161 A1, ;
Page/Page column 111-112 ;
WO 2008/023161 A1
反应条件
1: 60 percent / pyridine / 1) 0 to 5 deg C, 1h, 2) RT, overnight 2: 75 percent / pyridine / Heating 3: 1) EtOH, 1h, reflux, 2) 12h, reflux View Scheme
参考文献
Journal of the Indian Chemical Society, , vol. 67, # 10 p. 852 - 854
反应条件
1: With hydrogenchloride; sodium nitrite in water 2: With water; sodium sulfite
参考文献
Stiff, Cory; Graber, David R.; Thorarensen, Atli; Wakefield, Brian D.; Marotti, Keith R.; Melchior, Earline P.; Sweeney, Michael T.; Han, Fusen; Rohrer, Douglas C.; Zurenko, Gary E.; Romero, Donna L.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 23 p. 6293 - 6297
反应条件
pyridine 1) 0 to 5 deg C, 1h, 2) RT, overnight;
参考文献
Journal of the Indian Chemical Society, , vol. 67, # 10 p. 852 - 854
反应条件
1: 60 percent / pyridine / 1) 0 to 5 deg C, 1h, 2) RT, overnight 2: 75 percent / pyridine / Heating 3: 1) EtOH, 1h, reflux, 2) 12h, reflux View Scheme
参考文献
Kulkarni; Bishnoi
Journal of the Indian Chemical Society, 1990 , vol. 67, # 10 p. 852 - 854
参考文献
WO2004/81008 A1, ;
Page 132 ;
WO 2004/081008 A1
参考文献
Molecules, , vol. 12, # 12 p. 2621 - 2642
