2-氨基-5-溴苯甲酸合成路线 （共 139 条）
反应条件
lithium aluminium tetrahydride; NaOH; sodium sulfate in tetrahydrofuran; water; ethyl acetate
参考文献
Universal Display Corporation
Patent: US2012/217868 A1, 2012 ;
参考文献
Bogert; Hand
Journal of the American Chemical Society, 1906 , vol. 28, p. 101
反应条件
1: With triethylamine in anhydrous dichloroethane
T=20°C; 16 h;
2: With sulfuric acid; acetic anhydride in anhydrous dichloroethane
T=55°C; 5 h; Product distribution / selectivity;
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2006/12577 A2, 2006 ;
Location in patent: Page/Page column 71 ;
反应条件
1: hydrogenchloride / water / 24 h / 20 °C
2: 24 h / 20 °C
3: acetic anhydride; sodium acetate / 2 h / 120 °C
4: trichlorophosphate / 0.75 h / Reflux
5: acetic acid / 2 h / Reflux
6: hydrogen / Raney Ni / tetrahydrofuran; methanol / 24 h / 20 °C
View Scheme
参考文献
INTELLIKINE, LLC; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina; WILSON, Troy, Edward; CAMPBELL, Simon, Fraser
Patent: WO2012/116237 A2, 2012 ;
WO 2012/116237 A2
反应条件
1: triethylamine / tetrahydrofuran; water / 3 h / 20 °C / |Inert atmosphere
2: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 0 - 20 °C / |Inert atmosphere
3: tetrahydrofuran / 18 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Kothandaraman, Prasath; Lauw, Sherman Jun Liang; Chan, Philip Wai Hong
Tetrahedron, 2013 , vol. 69, # 35 p. 7471 - 7480
反应条件
2: aqueous ethanol; N2H4
View Scheme
参考文献
Cairncross; Bogert
Collection of Czechoslovak Chemical Communications, 1935 , vol. 7, p. 548,550, 553
反应条件
hydrogenchloride; anhydrous iron chloride in 1-methyl-pyrrolidin-2-one; water
T=60°C; 1 h; Reflux;
参考文献
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; LANDRY, Donald, W.; DENG, Shixian; ARANCIO, Ottavio; FIORITO, Joie; WASMUTH, Andrew
Patent: WO2013/109738 A1, 2013 ;
Location in patent: Paragraph 00140; 00141 ;
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in DMF (N,N-dimethyl-formamide); water
T=80°C; 15 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2003/97641 A2, 2003 ;
Location in patent: Page/Page column 70 ;
WO 03/097641 A2
反应条件
in tetrahydrofuran; water
参考文献
Bristol-Myers Squibb Company
Patent: US6011029 A1, 2000 ;
反应条件
isopentyl nitrite in ethylene glycol dimethyl ether
T=70°C; 1.16667 h;
参考文献
Kim, Bongsoo; Choi, Seong Ho; Zhu; Frisbie, C. Daniel
Journal of the American Chemical Society, 2011 , vol. 133, # 49 p. 19864 - 19877
