2-氨基-5-溴苯甲酸合成路线 （共 139 条）
反应条件
1: 2-amino-5-bromo-benzoic acid With ammonia 1 h; Heating / reflux; 2: acetic anhydride 4 h; Heating / reflux; 3: With water 0.5 h; Heating / reflux;
参考文献
Gruenenthal GmbH
Patent: US2009/69320 A1, 2009 ;
Location in patent: Page/Page column 76 ;
反应条件
1: 2 h / Heating 2: ammonium acetate / 0.08 h / 170 - 180 °C View Scheme
参考文献
Varma, Rajendra S.; Bahadur, Surendra; Agnihotri, Anil K.
Journal of Chemical & Engineering Data, 1981 , vol. 26, # 1 p. 103 - 104
反应条件
1.2: n-BuLi / tetrahydrofuran 2.1: POCl3 View Scheme
参考文献
Boschelli, Diane H; Wang, Daniel Y; Ye, Fei; Yamashita, Ayako; Zhang, Nan; Powell, Dennis; Weber, Jennifer; Boschelli, Frank
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 15 p. 2011 - 2014
反应条件
1: HOBt; EDC*HCl; ammonia / dimethylformamide; H2O / 20 °C 2: 12 N HCl / 20 °C 3: SOCl2 / dimethylformamide / Heating View Scheme
参考文献
Sen; Singh
Journal of the Indian Chemical Society, 1959 , vol. 36, p. 787,789, 790
反应条件
1: Na2CO3 2: Na2CO3 3: Et3N / Heating View Scheme
参考文献
Onyeibor, Onyeka; Croft, Simon L.; Dodson, Hilary I.; Feiz-Haddad, Mohammad; Kendrick, Howard; Millington, Nicola J.; Parapini, Silvia; Phillips, Roger M.; Seville, Scott; Shnyder, Steven D.; Taramelli, Donatella; Wright, Colin W.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2701 - 2709
反应条件
1: chloroacetic acid; 2-amino-5-bromo-benzoic acid With sodium hydroxide in water Heating; 2: acetic anhydride With sodium acetate in water; N,N-dimethyl-formamide Heating;
参考文献
Nirogi, Ramakrishna V.S.; Deshpande, Amol D.; Kambhampati, Ramasastri; Badange, Rajesh Kumar; Kota, Laxman; Daulatabad, Anand V.; Shinde, Anil K.; Ahmad, Ishtiyaque; Kandikere, Vishwottam; Jayarajan, Pradeep; Dubey
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 346 - 349
反应条件
1: With hydrogenchloride; sodium nitrite in water T=0°C; 1 h; 2: With ammonium hydroxide; CuSO4‵5H2O; hydroxylamine hydrochloride; sodium hydroxide in water T=70°C; 1 h;
参考文献
Vonlanthen, David; Rotzler, Juergen; Neuburger, Markus; Mayor, Marcel
European Journal of Organic Chemistry, 2010 , # 1 p. 120 - 133
反应条件
hydrogenchloride; ammonia; sodium nitrite in 6N-sodium hydroxide; water
参考文献
TOKYO INSTITUTE OF TECHNOLOGY
Patent: EP1717258 A1, 2006 ;
反应条件
hydrogenchloride; sodium hydroxide; sodium hydrogencarbonate; sodium nitrite in water; acetic anhydride
参考文献
United States of America as represented by the Secretary of the Air Force
Patent: US5081256 A1, 1992 ;
参考文献
TargeGen, Inc.
Patent: US2005/282814 A1, 2005 ;
