2-氨基-5-溴苯甲酸合成路线 （共 139 条）
反应条件
T=170 - 180°C; 0.583333 h; Microwave irradiation;
参考文献
Lehmann, Hansjoerg; Lavecchia, Luigi
Organic Process Research and Development, 2010 , vol. 14, # 3 p. 650 - 656
反应条件
formamide in methanol; water
参考文献
Zeneca Limited
Patent: US5866572 A1, 1999 ;
US 5866572 A
反应条件
in ethanol 16 h; Heating / reflux;
参考文献
WO2008/89307 A2, ;
Page/Page column 44-45 ;
反应条件
T=210°C; Cycloaddition; 0.25 h;
参考文献
Chao, Qi; Deng, Lynn; Shih, Hsiencheng; Leoni, Lorenzo M.; Genini, Davide; Carson, Dennis A.; Cottam, Howard B.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 19 p. 3860 - 3873
反应条件
Erhitzen des Reaktionsgemisches nach Zusatz von Ammoniumcarbonat auf 210-220grad;
参考文献
Bogert; Hand
Journal of the American Chemical Society, 1906 , vol. 28, p. 101
反应条件
sodium hydride 1.) dioxane, 15 min, 2.) reflux, 24 h; Yield given. Multistep reaction;
参考文献
Malamas, Michael S.; Millen, Jane
Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1492 - 1503
反应条件
sodium carbonate in dichloromethane T=20 - 40°C; 25 h;
参考文献
Egger, Michael; Li, Xuqin; Mueller, Christine; Bernhardt, Guenther; Buschauer, Armin; Koenig, Burkhard
European Journal of Organic Chemistry, 2007 , # 16 p. 2643 - 2649
反应条件
1: With sulfuric acid 72 h; Reflux; 2: With sodium hydroxide pH=10 - 11;
参考文献
OSI PHARMACEUTICALS, LLC; CREW, Andrew, P.; DONG, Hanqing; FERRARO, Caterina; SHERMAN, Dan; SIU, Kam, W.
Patent: WO2012/74951 A1, 2012 ;
Location in patent: Page/Page column 50-51 ;
WO 2012/074951 A1
反应条件
triethylamine in N,N-dimethyl-formamide T=20°C; 48 h;
参考文献
Hadida Ruah, Sara S.; Miller, Mark T.; Bear, Brian; McCartney, Jason; Grootenhuis, Peter D. J.
Patent: US2008/9524 A1, 2008 ;
Location in patent: Page/Page column 410 ;
反应条件
triethylamine in ethyl acetate; N,N-dimethyl-formamide; Petroleum ether
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
