2-氨基-5-溴苯甲酸合成路线 （共 139 条）
反应条件
hydrogenchloride; KNO2
参考文献
Huebner; Heinzerling
Zeitschrift fuer Chemie, 1871 , p. 710
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / -10 - 20 °C / Inert atmosphere 2: manganese(IV) oxide / dichloromethane / 20 °C View Scheme
参考文献
BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.
Patent: WO2014/11900 A2, 2014 ;
反应条件
potassium carbonate in acetone Heating;
参考文献
Zhao, Jian; Larock, Richard C.
Journal of Organic Chemistry, 2007 , vol. 72, # 2 p. 583 - 588
反应条件
1: borane-THF / tetrahydrofuran / 0 - 20 °C 2: manganese(IV) oxide / dichloromethane / 20 °C 3: neat (no solvent) / 5 h / 180 °C View Scheme
参考文献
BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.
Patent: WO2014/11900 A2, 2014 ;
反应条件
1: hydrogenchloride / water / 24 h / 20 °C 2: 24 h / 20 °C 3: acetic anhydride; sodium acetate / 2 h / 120 °C View Scheme
参考文献
INTELLIKINE, LLC; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina; WILSON, Troy, Edward; CAMPBELL, Simon, Fraser
Patent: WO2012/116237 A2, 2012 ;
WO 2012/116237 A2
反应条件
acetic acid in polyethyleneglycol (PEG-400) T=20 - 60°C; 0.166667 h;
参考文献
Chinese Chemical Letters, , vol. 23, # 4 p. 431 - 433
参考文献
Synlett, , vol. 24, # 16 art. no. ST-2013-B0671-L, p. 2102 - 2106
反应条件
1: 30 percent / conc. HCl / o-xylene / 6 h / Heating 2: conc. H2SO4 / dimethylsulfoxide / 20 °C View Scheme
参考文献
Chemistry of Heterocyclic Compounds, , vol. 42, # 4 p. 540 - 545
反应条件
in tetrahydrofuran; diethyl ether T=0 - 20°C;
参考文献
Zhang, Puwen; Kern, Jeffrey C.; Terefenko, Eugene A.; Fensome, Andrew; Unwalla, Ray; Zhang, Zhiming; Cohen, Jeffrey; Berrodin, Thomas J.; Yudt, Matthew R.; Winneker, Richard C.; Wrobel, Jay
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 13 p. 6589 - 6600
反应条件
1: T=180°C; 12 h; 2: With water
参考文献
ASTRAZENECA AB
Patent: US2009/170849 A1, 2009 ;
Location in patent: Page/Page column 11 ;
US 20090170849 A1
