(3,4-二苯甲酰氧基-5-硫代氨基甲酰四氢呋喃-2-基)甲基苯甲酸酯合成路线 （共 10 条）
反应条件
1.1: NaHCO3 / 1,2-dimethoxy-ethane / 6 h / 0 °C 1.2: TFAA; 2,6-lutidine / 1,2-dimethoxy-ethane / 2 h / -15 °C 2.1: 83 percent / NaOEt / ethanol / 12 h / 20 °C 3.1: NH3 / methanol / 12 h / 20 °C View Scheme
参考文献
Srivastava; Pickering; Allen; Streeter; Campbell; Witkowski; Sidwell; Robins
Journal of Medicinal Chemistry, 1977 , vol. 20, # 2 p. 256 - 262
反应条件
4-(N,N-dimethlyamino)pyridine in ethanol; dichloromethane
参考文献
The United States of America as represented by the Department of Health and Human Services
Patent: US4451648 A1, 1984 ;
反应条件
4-(N,N-dimethlyamino)pyridine; hydrogen sulfide in ethanol
Addition; 18 h;
参考文献
Ramasamy, Kanda S.; Averett, Devron
Nucleosides and Nucleotides, 1999 , vol. 18, # 11-12 p. 2425 - 2431
反应条件
in ethanol; water; dimethyl sulfoxide; ethyl acetate
参考文献
ICN Pharmaceuticals, Inc.
Patent: US5907036 A1, 1999 ;
反应条件
1: 75 percent / SnCl4 / CH2Cl2
2: 97 percent / H2S; DMAP / ethanol / 18 h
View Scheme
参考文献
Ramasamy, Kanda S.; Averett, Devron
Nucleosides and Nucleotides, 1999 , vol. 18, # 11-12 p. 2425 - 2431
参考文献
ICN Pharmaceuticals, Inc.
Patent: US5907036 A1, 1999 ;
参考文献
Srivastava; Pickering; Allen; Streeter; Campbell; Witkowski; Sidwell; Robins
Journal of Medicinal Chemistry, 1977 , vol. 20, # 2 p. 256 - 262
参考文献
Srivastava; Pickering; Allen; Streeter; Campbell; Witkowski; Sidwell; Robins
Journal of Medicinal Chemistry, 1977 , vol. 20, # 2 p. 256 - 262
反应条件
1: acetonitrile
2: NH3 / methanol / 96 h / Ambient temperature
View Scheme
参考文献
Srivastava; Pickering; Allen; Streeter; Campbell; Witkowski; Sidwell; Robins
Journal of Medicinal Chemistry, 1977 , vol. 20, # 2 p. 256 - 262
反应条件
1: Na2CO3 / benzene / Heating
2: NH3 / methanol
View Scheme
参考文献
Srivastava; Pickering; Allen; Streeter; Campbell; Witkowski; Sidwell; Robins
Journal of Medicinal Chemistry, 1977 , vol. 20, # 2 p. 256 - 262
