2-(2,2,2-三氟乙氧基)苯胺合成路线 (共 4 条)
反应条件
iron; acetic acid in ethanol 2 h; Reflux;
参考文献
BIOGEN IDEC MA INC.; CHAO, Jianhua; ENYEDY, Istvan, J.; GUERTIN, Kevin; HUTCHINGS, Richard, H.; JONES, John, Howard; POWELL, Noel; VANVLOTEN, Kurt, D.
Patent: WO2014/8214 A1, 2014 ;
Location in patent: Paragraph 00500; 00502 ;
反应条件
sodium hydroxide in acetic acid
参考文献
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Patent: EP966466 B1, 2002 ;
反应条件
potassium carbonate in ethanol; N,N-dimethyl-formamide
参考文献
US5859014 A1, ;
US 5859014 A
反应条件
1: K2CO3 / dimethylformamide / 15 h / 140 °C 2: H2 / 10percent Pd/C / ethanol / 16 h / 760 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 17 p. 2674 - 2687