1: (2R,4S)-4-[(8aS)-6-oxo-octahydropyrrolo[1,2-a]piperazin-2-yl]-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide hydrochloride With ammonia in water; ethyl acetate 2: cis-maleic acid in 2,2,4-trimethylpentane; isopropyl alcohol Product distribution / selectivity;

1: in isopropyl alcohol 1 h; 2: Industry scale; Product distribution / selectivity;

1: in isopropyl alcohol 2.5 h; 2: in 2,2,4-trimethylpentane; isopropyl alcohol 3.33333 h; Product distribution / selectivity;