1: With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane T=80°C; 15.1667 h; 2: With sodium hydroxide in diethyl ether; water 3: With hydrogenchloride in water T=10°C; pH=6.5;
参考文献
ASTRAZENECA AB
Patent: WO2006/65215 A1, 2006 ;
Location in patent: Page/Page column 29 ;
WO 2006/065215 A1
1: cyclopropyl-magnesium bromide With zinc(II) chloride in tetrahydrofuran
T=20°C; 2 h;
2: 2,5-dibromo-pyridine With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in tetrahydrofuran
T=20°C;
3: With hydrogenchloride; sodium hydroxide
more than 3 stages;
参考文献
ASTRAZENECA AB
Patent: WO2006/65215 A1, 2006 ;
Location in patent: Page/Page column 28 ;
WO 2006/065215 A1