4-(3-氯苯基)-2,4-二氧代丁酸乙酯合成路线 （共 6 条）
反应条件
1: N2H4*H2O; AcOH / 8 h / Heating 2: 64 percent / aq. NaOH / dioxane / 18 h / 20 °C View Scheme
参考文献
Van Herk; Brussee; Van den Nieuwendijk; Van der Klein; IJzerman; Stannek; Burmeister; Lorenzen
Journal of Medicinal Chemistry, 2003 , vol. 46, # 18 p. 3945 - 3951
反应条件
sodium hydride in DMF (N,N-dimethyl-formamide)
T=0 - 80°C; 1.5 h;
参考文献
AstraZeneca AB; NPS PHARMACEUTICALS, INC.
Patent: US2007/259895 A1, 2007 ;
Location in patent: Page/Page column 9 ;
US 20070259895 A1
反应条件
hydroxylamine hydrochloride in ethanol
T=5 - 60°C;
参考文献
ASTRAZENECA AB; AaSTROeM, Hans; JONES, Elfyn
Patent: WO2010/71558 A1, 2010 ;
Location in patent: Page/Page column 12 ;
反应条件
hydroxylamine hydrochloride in methanol
T=80°C; 4 h;
参考文献
ASTRA ZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2004/14881 A2, 2004 ;
Location in patent: Page 158 ;
WO 2004/014881 A2
反应条件
hydroxylamine hydrochloride
T=80°C; 4 h;
参考文献
ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2004/14370 A2, 2004 ;
Location in patent: Page/Page column 68 ;
WO 2004/014370 A2
反应条件
1: hydroxylamine hydrochloride / ethanol / 6 h / Reflux
2: sodium tetrahydroborate / tetrahydrofuran; ethanol / 4 h / 0 °C
View Scheme
参考文献
Lopopolo, Gianfranco; Fiorella, Filomena; De Candia, Modesto; Nicolotti, Orazio; Martel, Sophie; Carrupt, Pierre-Alain; Altomare, Cosimo
European Journal of Pharmaceutical Sciences, 2011 , vol. 42, # 3 p. 180 - 191
