4,4,4-三氟-1-(3-甲氧基苯基)-1,3-丁二酮合成路线 (共 1 条)
反应条件
1: (3-methoxyphenyl)acetoaldehyde With sodium hydride in tetrahydrofuran T=-5 - 0°C; 0.5 h; Inert atmosphere; 2: ethyl-α,α,α-trifluoroacetate in tetrahydrofuran T=-5 - 20°C; Claisen condensation; 6 h; Inert atmosphere; 3: With hydrogenchloride in water pH=6; Cooling with ice;
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 9 p. 4760 - 4767