1,3-苯并二氧代-2-羧酸甲酯合成路线 （共 3 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 1 h; 2: With sodium hydrogencarbonate in tetrahydrofuran; methanol; water T=0 - 20°C; 0.5 h;
参考文献
SHIONOGI and CO., LTD.; EURO-CELTIQUE S.A
Patent: WO2008/8398 A2, 2008 ;
Location in patent: Page/Page column 364-365 ;
反应条件
sodium hydride in N,N-dimethyl-formamide
T=95°C; 3 h;
参考文献
Torisu, Kazuhiko; Kobayashi, Kaoru; Iwahashi, Maki; Nakai, Yoshihiko; Onoda, Takahiro; Nagase, Toshihiko; Sugimoto, Isamu; Okada, Yutaka; Matsumoto, Ryoji; Nanbu, Fumio; Ohuchida, Shuichi; Nakai, Hisao; Toda, Masaaki
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 20 p. 5361 - 5378
反应条件
1: aq. NH3 / acetonitrile / 2 h / 23 °C
2: LiAlH4 / tetrahydrofuran / 24 h / 23 °C
View Scheme
参考文献
McComsey, David F.; Smith-Swintosky, Virginia L.; Parker, Michael H.; Brenneman, Douglas E.; Malatynska, Ewa; White, H. Steve; Klein, Brian D.; Wilcox, Karen S.; Milewski, Michael E.; Herb, Mark; Finley, Michael F. A.; Liu, Yi; Lubin, Mary Lou; Qin, Ning; Reitz, Allen B.; Maryanoff, Bruce E.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 22 p. 9019 - 9030
