7,8-二氯-1,2,3,4-四氢异喹啉鎓氯化物合成路线 （共 10 条）
反应条件
in ethanol; dichloromethane
参考文献
SmithKline Corporation
Patent: US4242346 A1, 1980 ;
反应条件
ammonium chloride; aluminium trichloride
T=185°C; 15 h;
参考文献
Mendelson, W. L.; Spainhour, C. B.; Jones, S. S.; Lam, B. L.; Wert, K. L.
Tetrahedron Letters, 1980 , vol. 21, p. 1393 - 1396
反应条件
1: 100 percent / benzene / Heating
2: concd. H2SO4 / 0.5 h / 140 - 150 °C
3: H2 / PtO2 / methanol / 25 °C / 3102.9 Torr
4: acetic anhydride / acetic acid / 1 h / Heating
5: 16.7 g / 12 N HCl / 4 h / Heating
View Scheme
参考文献
Bondinell; Chapin; Girard; Kaiser; Krog; Pavloff; Schwartz; Silvestri; Vaidya; Lam; Wellman; Pendleton
Journal of Medicinal Chemistry, 1980 , vol. 23, # 5 p. 506 - 511
反应条件
hydrogenchloride
4 h; Heating;
参考文献
Perchonock; Lantos; Finkelstein; Holden
Journal of Organic Chemistry, 1980 , vol. 45, # 10 p. 1950 - 1953
反应条件
1: H2 / PtO2 / methanol / 25 °C / 3102.9 Torr
2: acetic anhydride / acetic acid / 1 h / Heating
3: 16.7 g / 12 N HCl / 4 h / Heating
View Scheme
参考文献
Bondinell; Chapin; Girard; Kaiser; Krog; Pavloff; Schwartz; Silvestri; Vaidya; Lam; Wellman; Pendleton
Journal of Medicinal Chemistry, 1980 , vol. 23, # 5 p. 506 - 511
反应条件
1: concd. H2SO4 / 0.5 h / 140 - 150 °C
2: H2 / PtO2 / methanol / 25 °C / 3102.9 Torr
3: acetic anhydride / acetic acid / 1 h / Heating
4: 16.7 g / 12 N HCl / 4 h / Heating
View Scheme
参考文献
Bondinell; Chapin; Girard; Kaiser; Krog; Pavloff; Schwartz; Silvestri; Vaidya; Lam; Wellman; Pendleton
Journal of Medicinal Chemistry, 1980 , vol. 23, # 5 p. 506 - 511
反应条件
1: 86 percent / H2 / PtO2 / tetrahydrofuran / 3 h / 1034.3 Torr
2: 85 percent / 12N HCl / 4 h / Heating
View Scheme
参考文献
Perchonock; Lantos; Finkelstein; Holden
Journal of Organic Chemistry, 1980 , vol. 45, # 10 p. 1950 - 1953
反应条件
1: 79 percent / AlCl3 / CH2Cl2 / 0.17 h / Ambient temperature
2: 86 percent / H2 / PtO2 / tetrahydrofuran / 3 h / 1034.3 Torr
3: 85 percent / 12N HCl / 4 h / Heating
View Scheme
参考文献
Perchonock; Lantos; Finkelstein; Holden
Journal of Organic Chemistry, 1980 , vol. 45, # 10 p. 1950 - 1953
反应条件
1: acetic anhydride / acetic acid / 1 h / Heating
2: 16.7 g / 12 N HCl / 4 h / Heating
View Scheme
参考文献
Bondinell; Chapin; Girard; Kaiser; Krog; Pavloff; Schwartz; Silvestri; Vaidya; Lam; Wellman; Pendleton
Journal of Medicinal Chemistry, 1980 , vol. 23, # 5 p. 506 - 511
反应条件
sodium acetate; acetic anhydride; acetic acid in isopropyl alcohol
参考文献
SmithKline Corporation
Patent: US3988339 A1, 1976 ;
