3-氨基-4-苯基-1H-吡唑合成路线 （共 13 条）
反应条件
hydrazine hydrate in 1,4-dioxane; methanol T=140°C; 0.166667 h;
参考文献
Wilson, Noel S.; Osuma, Augustine T.; Camp, Jennifer A.Van; Xu, Xiangdong
Tetrahedron Letters, 2012 , vol. 53, # 34 p. 4498 - 4501
反应条件
hydrazine monohydrobromide in ethanol; water T=110°C; 5 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 15 p. 4388 - 4392
反应条件
ethanol; platinum Hydrogenation;
参考文献
Journal of the American Chemical Society, , vol. 73, p. 4664
反应条件
hydrazine hydrate; acetic acid in ethanol T=50°C; 7 h; Overall yield = 75 percent;
参考文献
Russian Journal of Organic Chemistry, , vol. 48, # 8 p. 1111 - 1120
Zh. Org. Khim., , vol. 48, # 8 p. 1113 - 1121,9
反应条件
1: DMA / toluene / Heating 2: N2H2*HCl / ethanol / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 19 p. 2767 - 2770
反应条件
in ethanol; acetic acid T=170°C; 0.166667 h; microwave irradiation;
参考文献
Daniels, R. Nathan; Kim, Kwangho; Lebois, Evan P.; Muchalski, Hubert; Hughes, Mary; Lindsley, Craig W.
Tetrahedron Letters, 2008 , vol. 49, # 2 p. 305 - 310
反应条件
in ethanol; acetic acid T=110°C; 6 h;
参考文献
Cuny, Gregory D.; Yu, Paul B.; Laha, Joydev K.; Xing, Xuechao; Liu, Ji-Feng; Lai, Carol S.; Deng, Donna Y.; Sachidanandan, Chetana; Bloch, Kenneth D.; Peterson, Randall T.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 15 p. 4388 - 4392
反应条件
hydrogenchloride; sodium nitrite in water T=0 - 5°C; 0.75 h;
参考文献
Ege, Guenter; Heck, Reinhard; Gilbert, Karlheinz; Irngartinger, Hermann; Huber-Patz, Ursula; Rodewald, Hans
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1629 - 1639
反应条件
1: ethyl acetate; formic acid ethyl ester With sodium in toluene
T=20 - 50°C;
2: 5-amino-4-phenyl-1Н-pyrazole in ethanol; toluene
Reflux;
参考文献
BioMarin IGA, Ltd.; WREN, Stephen Paul; WYNNE, Graham Michael; LECCI, Cristina; WILSON, Francis Xavier
Patent: WO2010/86040 A1, 2010 ;
Location in patent: Page/Page column 98-99 ;
反应条件
in ethanol
5 h; Heating;
参考文献
Senga; Novinson; Wilson; Robins
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 610 - 613
