反应条件
1: 1.) α-acetoxyisobutyryl bromide; 2.) Dowex 1x2 (OH-) resin / 1.) MeCN/H2O, RT, 1 h; 2.) MeOH, RT, 15 min
2: 87 percent / pyridine / 16 h / Ambient temperature
3: 90 percent / Et3N, (CH3)2BBr / CH2Cl2 / 0.25 h / -78 °C
4: 93 percent / Et3N / tetrahydrofuran; acetonitrile / 72 h / Ambient temperature
5: 10 percent / NaH / dimethylformamide / 1.) -5 to 0 deg C, 1 h; 2.) RT, 30 min
6: 69 percent / H2 / 5 percent Pd/C / aq. ethanol / 96 h / 760 Torr
View Scheme
参考文献
Schirmeister-Tichy, Helga; Iacono, Kathryn T.; Muto, Nicholas F.; Homan, Joseph W.; Suhadolnik, Robert J.; Pfleiderer, Wolfgang
Helvetica Chimica Acta, 1999 , vol. 82, # 4 p. 597 - 613
