反应条件
1: 2.) t-butyl hydroperoxide / 1.) -78 deg C, 1h; 2.) 0 deg C, 10 min, THF 2: 1.) n-C4H9NH2-HCOOH 2.) aq. HCl / 1.) Pd(P(C6H5)3)4/P(C6H5)3 / 1.) THF, 50 deg C, 6 h; 2.) 25 deg C, 18 h 3: 97 percent / dipyridyl disulfide, P(C6H5)3 / dimethylformamide; dimethylsulfoxide / 0.67 h / 25 °C 4: 80 percent / tributylammonium pyrophosphate / dimethylformamide / 72 h / 25 °C 5: bacterial alkaline phosphatase 6: snake venom phosphodiesterase / 17 h / 37 °C / pH=7.5 View Scheme
参考文献
Tetrahedron Letters, , vol. 28, # 23 p. 2623 - 2626
