生物素合成路线 - 魔法化学

生物素合成路线（共 172 条）

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反应条件

1.1: 62 percent / BF3*Et2O / CH2Cl2 / 0.25 h / -78 - 20 °C 2.1: NaBH4 / methanol / 4 h / 0 - 20 °C 2.2: 93 percent / TMSCl / 4 h / 40 °C 3.1: NaIO4 / acetone; H2O / 0.5 h / 20 °C 4.1: p-TSA / benzene / 6 h / Heating 5.1: 95 percent / Pd-CaCO3 / methanol / 24 h / 20 °C 6.1: DBU / toluene / 24 h / Heating 7.1: NaBH4 / ethanol / 2 h / Heating 8.1: 74 percent / Et3N; DMAP / 4 h / 0 - 20 °C 9.1: 78 percent / Na2S / dimethylformamide / 2 h / 100 °C 10.1: 82 percent / aq. HCl / acetic acid / 24 h / 20 °C 11.1: 89 percent / CH2Cl2 / 12 h / 20 °C 12.1: 97 percent / aq. NaOH / methanol / 12 h / 0 °C 13.1: 96 percent / H2 / 10percent Pd/C / 8 h / 2280.15 Torr 14.1: 80 percent / 48percent HBr / 2 h / Heating View Scheme

参考文献

Tetrahedron Letters, , vol. 45, # 39 p. 7307 - 7310

780767-60-4

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58-85-5生物素

反应条件

1: 95 percent / Pd-CaCO3 / methanol / 24 h / 20 °C 2: DBU / toluene / 24 h / Heating 3: NaBH4 / ethanol / 2 h / Heating 4: 74 percent / Et3N; DMAP / 4 h / 0 - 20 °C 5: 78 percent / Na2S / dimethylformamide / 2 h / 100 °C 6: 82 percent / aq. HCl / acetic acid / 24 h / 20 °C 7: 89 percent / CH2Cl2 / 12 h / 20 °C 8: 97 percent / aq. NaOH / methanol / 12 h / 0 °C 9: 96 percent / H2 / 10percent Pd/C / 8 h / 2280.15 Torr 10: 80 percent / 48percent HBr / 2 h / Heating View Scheme

参考文献

Tetrahedron Letters, , vol. 45, # 39 p. 7307 - 7310

780767-56-8

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58-85-5生物素

反应条件

1.1: NaIO4 / acetone; H2O / 0.5 h / 20 °C 2.1: Et3N; DMAP / 1,2-dichloro-ethane / 4 h / Heating 3.1: 62 percent / BF3*Et2O / CH2Cl2 / 0.25 h / -78 - 20 °C 4.1: NaBH4 / methanol / 4 h / 0 - 20 °C 4.2: 93 percent / TMSCl / 4 h / 40 °C 5.1: NaIO4 / acetone; H2O / 0.5 h / 20 °C 6.1: p-TSA / benzene / 6 h / Heating 7.1: 95 percent / Pd-CaCO3 / methanol / 24 h / 20 °C 8.1: DBU / toluene / 24 h / Heating 9.1: NaBH4 / ethanol / 2 h / Heating 10.1: 74 percent / Et3N; DMAP / 4 h / 0 - 20 °C 11.1: 78 percent / Na2S / dimethylformamide / 2 h / 100 °C 12.1: 82 percent / aq. HCl / acetic acid / 24 h / 20 °C 13.1: 89 percent / CH2Cl2 / 12 h / 20 °C 14.1: 97 percent / aq. NaOH / methanol / 12 h / 0 °C 15.1: 96 percent / H2 / 10percent Pd/C / 8 h / 2280.15 Torr 16.1: 80 percent / 48percent HBr / 2 h / Heating View Scheme

参考文献

Tetrahedron Letters, , vol. 45, # 39 p. 7307 - 7310

780767-59-1

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58-85-5生物素

反应条件

1: NaIO4 / acetone; H2O / 0.5 h / 20 °C 2: p-TSA / benzene / 6 h / Heating 3: 95 percent / Pd-CaCO3 / methanol / 24 h / 20 °C 4: DBU / toluene / 24 h / Heating 5: NaBH4 / ethanol / 2 h / Heating 6: 74 percent / Et3N; DMAP / 4 h / 0 - 20 °C 7: 78 percent / Na2S / dimethylformamide / 2 h / 100 °C 8: 82 percent / aq. HCl / acetic acid / 24 h / 20 °C 9: 89 percent / CH2Cl2 / 12 h / 20 °C 10: 97 percent / aq. NaOH / methanol / 12 h / 0 °C 11: 96 percent / H2 / 10percent Pd/C / 8 h / 2280.15 Torr 12: 80 percent / 48percent HBr / 2 h / Heating View Scheme

参考文献

Tetrahedron Letters, , vol. 45, # 39 p. 7307 - 7310

780767-55-7

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58-85-5生物素

反应条件

1.1: 98 percent / p-TSA / tetrahydrofuran; H2O / 6 h / Heating 2.1: NaIO4 / acetone; H2O / 0.5 h / 20 °C 3.1: Et3N; DMAP / 1,2-dichloro-ethane / 4 h / Heating 4.1: 62 percent / BF3*Et2O / CH2Cl2 / 0.25 h / -78 - 20 °C 5.1: NaBH4 / methanol / 4 h / 0 - 20 °C 5.2: 93 percent / TMSCl / 4 h / 40 °C 6.1: NaIO4 / acetone; H2O / 0.5 h / 20 °C 7.1: p-TSA / benzene / 6 h / Heating 8.1: 95 percent / Pd-CaCO3 / methanol / 24 h / 20 °C 9.1: DBU / toluene / 24 h / Heating 10.1: NaBH4 / ethanol / 2 h / Heating 11.1: 74 percent / Et3N; DMAP / 4 h / 0 - 20 °C 12.1: 78 percent / Na2S / dimethylformamide / 2 h / 100 °C 13.1: 82 percent / aq. HCl / acetic acid / 24 h / 20 °C 14.1: 89 percent / CH2Cl2 / 12 h / 20 °C 15.1: 97 percent / aq. NaOH / methanol / 12 h / 0 °C 16.1: 96 percent / H2 / 10percent Pd/C / 8 h / 2280.15 Torr 17.1: 80 percent / 48percent HBr / 2 h / Heating View Scheme

参考文献

Tetrahedron Letters, , vol. 45, # 39 p. 7307 - 7310

780767-58-0

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58-85-5生物素

反应条件

1.1: NaBH4 / methanol / 4 h / 0 - 20 °C 1.2: 93 percent / TMSCl / 4 h / 40 °C 2.1: NaIO4 / acetone; H2O / 0.5 h / 20 °C 3.1: p-TSA / benzene / 6 h / Heating 4.1: 95 percent / Pd-CaCO3 / methanol / 24 h / 20 °C 5.1: DBU / toluene / 24 h / Heating 6.1: NaBH4 / ethanol / 2 h / Heating 7.1: 74 percent / Et3N; DMAP / 4 h / 0 - 20 °C 8.1: 78 percent / Na2S / dimethylformamide / 2 h / 100 °C 9.1: 82 percent / aq. HCl / acetic acid / 24 h / 20 °C 10.1: 89 percent / CH2Cl2 / 12 h / 20 °C 11.1: 97 percent / aq. NaOH / methanol / 12 h / 0 °C 12.1: 96 percent / H2 / 10percent Pd/C / 8 h / 2280.15 Torr 13.1: 80 percent / 48percent HBr / 2 h / Heating View Scheme

参考文献

Tetrahedron Letters, , vol. 45, # 39 p. 7307 - 7310

863203-60-5

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58-85-5生物素

反应条件

1: 47.8 g / ZnCl2; H2 / 5 percent Pd/C / toluene / 6 h / 110 °C / 30400 Torr 2: 75 percent / glacial acetic acid; H2SO4 / H2O / 12 h / Heating View Scheme

参考文献

Tetrahedron Asymmetry, , vol. 14, # 23 p. 3667 - 3672

541508-57-0

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58-85-5生物素

反应条件

1.1: 93 percent / H2O2; K2CO3 / dimethylsulfoxide 2.1: dimethylformamide / 1 h / 90 °C 3.1: 95.1 g / conc. HCl / dimethylformamide / 3 h / 90 °C 4.1: DCC; pyridine; TFA / CHCl3 / 1 h / 10 °C 5.1: 88.1 g / pyridine / CHCl3 / 6 h / 60 °C 6.1: Pd(OH)2/C / tetrahydrofuran; toluene; dimethylformamide / 30 °C 6.2: 92 percent / HCl / tetrahydrofuran; toluene; dimethylformamide 7.1: hydrogen / Pd(OH)2/C / aq. methanol / 6750.54 Torr 7.2: 90 percent / NaOH / aq. methanol 8.1: 74 percent / MeSO3H / 1,3,5-trimethyl-benzene View Scheme

参考文献

Tetrahedron Letters, , vol. 44, # 49 p. 8905 - 8907

333355-49-0

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58-85-5生物素

反应条件

1.1: hydrogen / Pd(OH)2/C / aq. methanol / 6750.54 Torr 1.2: 90 percent / NaOH / aq. methanol 2.1: 74 percent / MeSO3H / 1,3,5-trimethyl-benzene View Scheme

参考文献

Tetrahedron Letters, , vol. 44, # 49 p. 8905 - 8907

5414-21-15-溴戊腈

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58-85-5生物素

反应条件

1.1: 90 percent / NaI / acetone / 6 h / Heating 2.1: Zn; TMSCl; 1,2-dibromoethane / tetrahydrofuran / 30 °C 2.2: 80 percent / 5 percent Ni/C / toluene; dimethylformamide; tetrahydrofuran / 30 h / 20 °C 3.1: 92 percent / H2 / Pd(OH)2/C / ethyl acetate / 6 h / 30 °C / 3040 Torr 4.1: aq. HBr / toluene / 40 h / Heating 5.1: 22 g / aq. NaOH / toluene; methoxybenzene / 6 h / 30 °C View Scheme

参考文献

Synthesis, , # 14 p. 2155 - 2160

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