反应条件
1: pyridine / dichloromethane / 8 h / 0 - 20 °C
2: bromine; pyridine / tetrachloromethane / 3 h / 0 - 90 °C
3: potassium carbonate; water / methanol / 2 h / 20 °C
4: potassium carbonate / acetone / 20 °C
5: potassium tert-butylate; tris-(dibenzylideneacetone)dipalladium(0); 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene / toluene / 8.16 h / 100 °C / |Inert atmosphere
6: palladium 10 on activated carbon; hydrogen / methanol / 8 h / 60 °C / 760.05 Torr
View Scheme
参考文献
NOVARTIS AG; CHEN, Chao; DENG, Haibing; GUO, Haibing; HE, Feng; JIANG, Lei; LIANG, Fang; MI, Yuan; WAN, Huixin; XU, Yao-Chang; YU, Hongping; ZHANG, Ji Yue
Patent: US2013/245002 A1, 2013 ;