(9ci)-1-甲基-1H-苯并咪唑-2-甲腈合成路线 （共 10 条）
反应条件
1: 10 h / 80 °C 2: 95 percent / methanol / 0.17 h View Scheme
参考文献
Glowczyk, Joanna; Serafin, Barbara
Polish Journal of Chemistry, 1984 , vol. 58, # 1-3 p. 149 - 156
反应条件
in N,N-dimethyl-formamide
T=100°C; 2 h;
参考文献
Luo, Yu; Xiao, Feng; Qian, Shijing; Lu, Wei; Yang, Bo
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 417 - 422
反应条件
copper (I) cyanide; lithium tert-butylate in 1,4-dioxane; m-xylene
T=120°C; 12 h; Inert atmosphere; regioselective reaction;
参考文献
Do, Hien-Quang; Daugulis, Olafs
Organic Letters, 2010 , vol. 12, # 11 p. 2517 - 2519
反应条件
in chloroform
10 h; Ambient temperature;
参考文献
Castellanos, Maria Luisa; Llinas, Montserrat; Bruix, Marta; Mendoza, Javier de; Martin, M. Rosario
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1209 - 1216
反应条件
in tetrahydrofuran
5 h; Heating;
参考文献
Nagasaki, Izuru; Suzuki, Yumiko; Iwamoto, Ken-Ichi; Higashino, Takeo; Miyashita, Akira
Heterocycles, 1997 , vol. 46, # 1 p. 443 - 450
反应条件
1: 36 percent / pyridine / tetrahydrofuran / 1 h / Ambient temperature
2: 70 percent / benzene / 0.17 h / 80 °C
View Scheme
参考文献
Konstantinova, Lidia S.; Rakitin, Oleg A.; Rees, Charles W.; Sivadasan, Sivaprasad; Torroba, Tomas
Tetrahedron, 1998 , vol. 54, # 33 p. 9639 - 9650
参考文献
Konstantinova, Lidia S.; Rakitin, Oleg A.; Rees, Charles W.; Sivadasan, Sivaprasad; Torroba, Tomas
Tetrahedron, 1998 , vol. 54, # 33 p. 9639 - 9650
反应条件
n-butyllithium
1) THF, -78 deg C, 30 min, 2) THF, -78 deg C, 30 min then -78 deg C to RT, 2 h; Yield given. Multistep reaction;
参考文献
Nagasaki, Izuru; Suzuki, Yumiko; Iwamoto, Ken-Ichi; Higashino, Takeo; Miyashita, Akira
Heterocycles, 1997 , vol. 46, # 1 p. 443 - 450
反应条件
1: 76 percent / 0.25 h / 120 °C
2: 99 percent / CHCl3 / 10 h / Ambient temperature
View Scheme
参考文献
Castellanos, Maria Luisa; Llinas, Montserrat; Bruix, Marta; Mendoza, Javier de; Martin, M. Rosario
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1209 - 1216
反应条件
(NH4)2S; triethylamine in N,N-dimethyl-formamide
T=50°C; 2 h;
参考文献
Luo, Yu; Xiao, Feng; Qian, Shijing; Lu, Wei; Yang, Bo
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 417 - 422
