3-氯-6-(4-氯苯基)-哒嗪合成路线 （共 11 条）
反应条件
sodium carbonate; Pd(dppf)Cl2 in 1,4-dioxane; water
参考文献
US2004/209865 A1, ;
US 20040209865 A1
反应条件
chlorosulphonyl isocyanate in various solvent(s) T=60 - 65°C; 3.5 h;
参考文献
Srinivasan, T. N.; Rao, K. Rama; Satur, P. B.
Synthetic Communications, 1986 , vol. 16, # 5 p. 543 - 546
反应条件
sodium carbonate; chloro(di-2-norbornylphosphino)(2'-dimethylamino-1,1'-biphenyl-2-yl)palladium(II) in 1,4-dioxane; water T=110°C; 3 h;
参考文献
BOEHRINGER INGELHEIM
Patent: WO2004/39780 A1, 2004 ;
Location in patent: Page/Page column 129 ;
WO 2004/039780 A1
反应条件
bromine; trichlorophosphate in acetic acid
反应条件
sodium carbonate in 1,4-dioxane; water; ethyl acetate
参考文献
US2004/209865 A1, ;
US 20040209865 A1
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=20°C; 24 h;
参考文献
Tetrahedron Letters, , vol. 46, # 8 p. 1303 - 1305
反应条件
1: sodium acetate; hydrazine hydrate / methanol / 6 h / Reflux 2: trichlorophosphate / 6 h / Heating View Scheme
参考文献
Acta Poloniae Pharmaceutica - Drug Research, , vol. 67, # 5 p. 555 - 562
反应条件
1: AlCl3, aluminium chloride / Reflux 2: sodium acetate; hydrazine hydrate / methanol / 6 h / Reflux 3: trichlorophosphate / 6 h / Heating View Scheme
参考文献
Acta Poloniae Pharmaceutica - Drug Research, , vol. 67, # 5 p. 555 - 562
反应条件
trichlorophosphate 6 h; Heating;
参考文献
Acta Poloniae Pharmaceutica - Drug Research, , vol. 67, # 5 p. 555 - 562
反应条件
1: hydrazine hydrate / butan-1-ol / 6 h / 100 °C 2: H2 / Raney Ni / methanol / 20 °C / 760 Torr View Scheme
参考文献
Wermuth, Camille-Georges; Bourguignon, Jean-Jacques; Schlewer, Gilbert; Gies, Jean-Pierre; Schoenfelder, Angele; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 239 - 249
