3-氯-6-(3-硝基苯基)吡嗪合成路线 （共 7 条）
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water
T=80°C; 3 h;
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6770667 B1, 2004 ;
Location in patent: Page column 6-7 ;
反应条件
trichlorophosphate
1 h; Heating / reflux;
参考文献
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Patent: WO2008/30744 A2, 2008 ;
Location in patent: Page/Page column 54-55 ;
WO 2008/030744 A2
反应条件
sulfuric acid; nitric acid in water
T=0°C; 0.25 h;
参考文献
Basha, Anwer; Bunnelle, William H.; Dart, Michael J.; Gallagher, Megan E.; Ji, Jianguo; Li, Tao; Pace, Jennifer M.; Ryther, Keith B.; Tietje, Karin R.; Mortell, Kathleen H.; Nersesian, Diana L.; Schrimpf, Michael R.
Patent: US2005/101602 A1, 2005 ;
Location in patent: Page/Page column 43-44 ;
反应条件
1: 100 percent / Br2, HOAc / 1 h / Heating
2: 45 percent / POCl3 / Heating
View Scheme
参考文献
Albright, J. D.; Moran, D. B.; Wright, W. B.; Collins, J. B.; Beer, B.; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 592 - 600
反应条件
1: Hydrazine hydrochloride, KOH / H2O / 2 h / Heating
2: bromine / acetic acid / 1 h / Heating
3: POCl3, N,N-Dimethylaniline / 7 h / 130 °C
View Scheme
参考文献
Shkurko, O. P.; Kuznetsov, S. A.; Denisov, A. Yu.; Mamaev, V. P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1986 , vol. 22, # 7 p. 763 - 770
Khimiya Geterotsiklicheskikh Soedinenii, 1986 , vol. 22, # 7 p. 951 - 958
反应条件
hydrogen; palladium 10 on activated carbon in ethanol
T=20°C; 1 h;
参考文献
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Patent: WO2008/30744 A2, 2008 ;
Location in patent: Page/Page column 55 ;
WO 2008/030744 A2
反应条件
1: 73 percent / butan-1-ol / 48 h / Heating
2: 92 percent / H2 / 10percent Pd/C / trifluoroacetic acid / 1.5 h
View Scheme
参考文献
Albright, J. D.; Moran, D. B.; Wright, W. B.; Collins, J. B.; Beer, B.; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 592 - 600
