1,5,7-三氮杂双环[4.4.0]癸-5-烯合成路线 （共 17 条）
反应条件
in deuterated toluene T=24.84°C; Inert atmosphere; Kinetics;
参考文献
Journal of Organic Chemistry, , vol. 74, # 24 p. 9490 - 9496
参考文献
Shin-Etsu Chemical Co., Ltd.
Patent: EP2412733 A1, 2012 ;
反应条件
1: 66 percent / KOH, KBr, NaBH4 / toluene / 42.5 h / Ambient temperature 2: 94 percent / aq. H2SO4 / 9.5 h / Heating View Scheme
参考文献
Alexandrova, Anastasia V.; Masek, Tomas; Polyakova, Svetlana M.; Cisarova, Ivana; Saame, Jaan; Leito, Ivo; Lyapkalo, Ilya M.
European Journal of Organic Chemistry, 2013 , # 9 p. 1811 - 1823
参考文献
BP Chemicals Limited
Patent: US4700005 A1, 1987 ;
参考文献
BP Chemicals Limited
Patent: EP293811 A1, 1988 ;
反应条件
1: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine With sodium hydride in tetrahydrofuran
T=20°C; 3 h;
2: 1-bromo-butane in tetrahydrofuran
参考文献
Bell, Jason R.; Luo, Huimin; Dai, Sheng
Tetrahedron Letters, 2011 , vol. 52, # 29 p. 3723 - 3725
反应条件
1: -20 - 20 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / -78 - 20 °C
3: sulfuric acid / water / 5 h / |Reflux
4: tris-(dimethylamino)-phosphine / 96 h / 120 °C
View Scheme
参考文献
Alexandrova, Anastasia V.; Masek, Tomas; Polyakova, Svetlana M.; Cisarova, Ivana; Saame, Jaan; Leito, Ivo; Lyapkalo, Ilya M.
European Journal of Organic Chemistry, 2013 , # 9 p. 1811 - 1823
