N-(2-(苄基氨基)乙基)苯胺合成路线 （共 17 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
16 h; Heating;
参考文献
Bhatia, Pramila A.; Brooks, Clint D. W.; Basha, Anwer; Ratajczyk, James D.; Gunn, Bruce P.; Bouska, Jennifer B.; Lanni, Carmine; Young, Patrick R.; Bell, Randy L.; Carter, George W.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 20 p. 3938 - 3950
反应条件
in neat (no solvent)
T=150 - 165°C;
参考文献
Poindexter, Graham S.; Owens, Donald A.; Dolan, Peter L.; Woo, Edmund
Journal of Organic Chemistry, 1992 , vol. 57, # 23 p. 6257 - 6265
反应条件
hydrogenchloride
5 h; Heating;
参考文献
Dinsmore, Christopher J.; Bergman, Jeffrey M.
Journal of Organic Chemistry, 1998 , vol. 63, # 12 p. 4131 - 4134
反应条件
1: 2.) Et3N / 1.) CH2Cl2, 0 deg C, 2.) 45 min
2: 100 percent / HCl gas / ethyl acetate / 0.05 h / 0 °C
3: 72 percent / Na(OAc)3BH, 4A MS / 1,2-dichloro-ethane / 4 h / 0 - 20 °C / tandem reductive alkylation-cyclization of amines with various aldehydes and ketones to give 2m3-diketopiperazines
4: 81 percent / aq. HCl / 5 h / Heating
View Scheme
参考文献
Dinsmore, Christopher J.; Bergman, Jeffrey M.
Journal of Organic Chemistry, 1998 , vol. 63, # 12 p. 4131 - 4134
反应条件
1: 100 percent / HCl gas / ethyl acetate / 0.5 h / 0 °C
2: 16 percent / Na(OAc)3BH, 4A MS / 1,2-dichloro-ethane / 1.) 0 deg C, 30 min, 2.) room temperature, 4 h
3: 81 percent / aq. HCl / 5 h / Heating
View Scheme
参考文献
Dinsmore, Christopher J.; Bergman, Jeffrey M.
Journal of Organic Chemistry, 1998 , vol. 63, # 12 p. 4131 - 4134
反应条件
1: 87 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature
2: 99 percent / LiAlH4 / tetrahydrofuran / 16 h / Heating
View Scheme
参考文献
Bhatia, Pramila A.; Brooks, Clint D. W.; Basha, Anwer; Ratajczyk, James D.; Gunn, Bruce P.; Bouska, Jennifer B.; Lanni, Carmine; Young, Patrick R.; Bell, Randy L.; Carter, George W.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 20 p. 3938 - 3950
反应条件
1: 72 percent / Na(OAc)3BH, 4A MS / 1,2-dichloro-ethane / 4 h / 0 - 20 °C / tandem reductive alkylation-cyclization of amines with various aldehydes and ketones to give 2m3-diketopiperazines
2: 81 percent / aq. HCl / 5 h / Heating
View Scheme
参考文献
Dinsmore, Christopher J.; Bergman, Jeffrey M.
Journal of Organic Chemistry, 1998 , vol. 63, # 12 p. 4131 - 4134
反应条件
1: 100 percent / HCl gas / ethyl acetate / 0.05 h / 0 °C
2: 72 percent / Na(OAc)3BH, 4A MS / 1,2-dichloro-ethane / 4 h / 0 - 20 °C / tandem reductive alkylation-cyclization of amines with various aldehydes and ketones to give 2m3-diketopiperazines
3: 81 percent / aq. HCl / 5 h / Heating
View Scheme
参考文献
Dinsmore, Christopher J.; Bergman, Jeffrey M.
Journal of Organic Chemistry, 1998 , vol. 63, # 12 p. 4131 - 4134
反应条件
1: 1) NaH / 1) THF, DMF, RT, 24 h, 2) 24 h
2: 63 percent / neat (no solvent) / 150 - 165 °C
View Scheme
参考文献
Poindexter, Graham S.; Owens, Donald A.; Dolan, Peter L.; Woo, Edmund
Journal of Organic Chemistry, 1992 , vol. 57, # 23 p. 6257 - 6265
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
16 h; Heating;
参考文献
Lambert, Joseph B.; Huseland, Dave E.; Wang, Gen-tai
Synthesis, 1986 , # 8 p. 657 - 658
