(R)-3-羟基-gamma-丁内酯合成路线 （共 27 条）
反应条件
1: With sodium hydroxide in water T=40°C; 2 h; 2: With alpha,alpha-dimethylbenzyl hydroperoxide in water T=40 - 70°C; 8 h; 3: With sulfuric acid in water T=0 - 50°C; pH=1;
参考文献
Council of Scientific and Industrial Research
Patent: US6713639 B1, 2004 ;
Location in patent: Page column 5-6 ;
反应条件
sodium hydroxide in water T=0 - 10°C; pH=7.5 - 7.7;
参考文献
WO2005/30747 A1, ;
Page/Page column 5-6 ;
反应条件
1: With dimethylsulfide borane complex in tetrahydrofuran 1.08333 h; 2: With sodium tetrahydroborate in tetrahydrofuran T=20°C; Cooling with ice; 3: With toluene-4-sulfonic acid in tetrahydrofuran; ethanol T=20°C; 0.583333 h;
参考文献
Bode, Moira L.; Gates, Paul J.; Gebretnsae, Samson Y.; Vleggaar, Robert
Tetrahedron, 2010 , vol. 66, # 11 p. 2026 - 2036
反应条件
hydrogenchloride; Lipase PS; water; tri-(hydroxymethyl)-methylamine in acetone T=37°C; pH=7.0; 24 - 48 h; Product distribution / selectivity;
参考文献
WO2007/100227 A1, ;
Page/Page column 7-8 ;
参考文献
Tetrahedron Letters, , vol. 28, # 42 p. 5033 - 5036
反应条件
toluene-4-sulfonic acid in dichloromethane Ambient temperature;
参考文献
Uchikawa; Okukado; Sakata; Arase; Terada
Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 6 p. 2025 - 2029
反应条件
trifluoroacetic acid in dichloromethane 20 h; Ambient temperature;
参考文献
Saito, Seiki; Hasegawa, Takashi; Inaba, Masami; Nishida, Ryosuke; Fujii, Toshikazu; et. al
Chemistry Letters, 1984 , p. 1389 - 1392
反应条件
in dimethyl sulfoxide T=150°C; 2 h;
参考文献
Calvisi, Giuseppina; Catini, Roberto; Chiariotti, Wilma; Giannessi, Fabio; Muck, Sandra; Tinti, Maria Ornella; De Angelis, Francesco
Synlett, 1997 , vol. 1997, # 1 p. 71 - 74
反应条件
sodium tetrahydroborate in methanol; tert-butyl alcohol 2 h; Heating;
参考文献
Henrot, Serge; Larcheveque, Marc; Petit, Yves
Synthetic Communications, 1986 , vol. 16, # 2 p. 183 - 190
反应条件
toluene-4-sulfonic acid T=20°C; 48 h;
参考文献
Organic and biomolecular chemistry, , vol. 1, # 3 p. 552 - 559
